| Name | Pregnenolone |
| Description | Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease. |
| In vitro | Pregnenolone induces a large, dose-related increase of both the rate and extent of MAP2-induced tubulin assembly, whereas progesterone, inactive per se, counteracted the stimulatory effect of Pregnenolone. Pregnenolone-increased assembly of microtubules produces a completely normal structure. [1] Pregnenolone preserves microtubule abundance and promotes cell movement during epiboly. [2] Pregnenolone results in dramatic reduction in GR nuclear localization in mouse hippocampal cell line (HT-22). Pregnenolone has neuroprotective effects against both glutamate and amyloid beta protein neuropathology. [3] |
| In vivo | Pregnenolone sustains its proliferative activity in vivo and stimulates the growth of LNCaP-tumor xenografts in intact male SCID mice as well as in castrated animals. Pregnenolone is shown to activate transcription through the LNCaP androgen receptor (AR), but not the wild-type AR. [4] Pregnenolone results in a significant decrease in the accumulation of astrocytes in the proximity of the wound and in a decreased bromodeoxyuridine incorporation in reactive astrocytes of rats. [5] Pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and markedly increases GABA(A) receptor responses. Pregnenolone administration elevates pregnenolone sulfate, a neurosteroid that positively modulates NMDA receptors. [6] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 21 mg/mL (66.35 mM), Sonication is recommended.
DMSO : 3.33 mg/mL (10.53 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | TRPVChannel | TRPV Channel | TRPChannel | TRP Channel | Transient receptor potential channels | Pregnenolone | mAChR | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | CB | CannabinoidReceptor | Cannabinoid Receptor | Autophagy | 3b-Hydroxy-5-pregnen-20-one | 3beta-Hydroxy-5-pregnen-20-one |
| Inhibitors Related | Sucrose | Stavudine | Cysteamine hydrochloride | Hydroxychloroquine | Daidzein | Ferulic Acid | Paeonol | Glycerol | Thymidine | Naringin | Alginic acid | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Natural Product Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Human Endogenous Metabolite Library | Immunology/Inflammation Compound Library |
United States
