| 名称 | Pregnenolone |
| 描述 | Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease. |
| 体外活性 | Pregnenolone induces a large, dose-related increase of both the rate and extent of MAP2-induced tubulin assembly, whereas progesterone, inactive per se, counteracted the stimulatory effect of Pregnenolone. Pregnenolone-increased assembly of microtubules produces a completely normal structure. [1] Pregnenolone preserves microtubule abundance and promotes cell movement during epiboly. [2] Pregnenolone results in dramatic reduction in GR nuclear localization in mouse hippocampal cell line (HT-22). Pregnenolone has neuroprotective effects against both glutamate and amyloid beta protein neuropathology. [3] |
| 体内活性 | Pregnenolone sustains its proliferative activity in vivo and stimulates the growth of LNCaP-tumor xenografts in intact male SCID mice as well as in castrated animals. Pregnenolone is shown to activate transcription through the LNCaP androgen receptor (AR), but not the wild-type AR. [4] Pregnenolone results in a significant decrease in the accumulation of astrocytes in the proximity of the wound and in a decreased bromodeoxyuridine incorporation in reactive astrocytes of rats. [5] Pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and markedly increases GABA(A) receptor responses. Pregnenolone administration elevates pregnenolone sulfate, a neurosteroid that positively modulates NMDA receptors. [6] |
| 存储条件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 21 mg/mL (66.4 mM)
DMSO : 3.33 mg/mL (10.53 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| 关键字 | Pregnenolone | Cannabinoid Receptor | Transient receptor potential channels | inhibit | 3beta-Hydroxy-5-pregnen-20-one | TRP Channel | 3b-Hydroxy-5-pregnen-20-one | Autophagy | Endogenous Metabolite | Inhibitor |
| 相关产品 | Sucrose | Hydroxychloroquine | Glycerol | Thymidine |
| 相关库 | 中药单体化合物库 | 经典已知活性库 | 膜蛋白靶向化合物库 | 天然产物库 | 烟草单体化合物库 | 高通量筛选天然产物库 | 已知活性化合物库 | GPCR靶点分子库 | 抗癌药物库 |
United States
