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ChemicalBook Product Catalog Posatirelin

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Posatirelin NEW

$130.00 1mg

$320.00 5mg

$480.00 10mg

Min. Order
Purity98.22%
Cas No78664-73-0
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Posatirelin
CAS No	78664-73-0
EC-No
Min. Order
Purity	98.22%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Posatirelin
Description	Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.
In vivo	The pharmacokinetics and endocrine effects of a therapeutic dose (10 mg/day) of posatirelin were investigated in healthy elderly subjects. Posatirelin was given once daily by intramuscular injection for 7 days. Pharmacokinetic parameters were estimated using a model-independent approach. The plasma concentrations of free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) and the circadian rhythms of prolactin and cortisol were considered as indicators variables of endocrine response to posatirelin administration. Posatirelin was well tolerated and no significant adverse effects were observed during the study. There were no significant changes in these parameters after multiple-dose administration (day 7). Posatirelin induced a progressive reduction in basal TSH levels and maximum response. There were no significant changes during treatment in the time at which basal levels of FT3 and FT4 occurred, and these levels remained within the normal range throughout the study. The circadian rhythms of cortisol and prolactin were not influenced by posatirelin treatment. The pharmacokinetics of posatirelin were not time-dependent, and the drug did not accumulate after multiple-dose administration. Short-term treatment with posatirelin did not induce clinically relevant endocrine consequences in healthy elderly subjects.[1]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 25 mg/mL (70.94 mM)
Keywords	RGH2202 \| RGH 2202 \| Posatirelin
Inhibitors Related	Adiphenine hydrochloride \| Nanofin \| Arecoline hydrobromide \| Forskolin \| CLOZAPINE N-OXIDE \| Pilocarpine nitrate \| Ribavirin \| Adenine \| Choline chloride \| Propoxur
Related Compound Libraries	Anti-Neurodegenerative Disease Compound Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Bioactive Compounds Library Max

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