Manufacturer Provide CAS 1405-20-5 99% Polymyxin B Sulfate Powder
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Introduction
Name: Polymyxin B sulfate
Chemical name: POLYMYXIN B;POLYMYXIN-B 2,5-SULFATE;POLYMYXIN B SULFATE;POLYMYXIN B SULFATE
C.A.S NO. : 1405-20-5
Assay (%)(HPLC, Basis on drying):99%
Molecular formula: C56H100N16O17S
Molecular weight :1301.56
Characteristic: White crystalline powder
Melting point: 217-220°C (dec.)
Solubility: Soluble in water at 50mg/ml/n
Polymyxin B sulfate is similar with polymyxin E, and has either bacteriostatic or bactericidal effect on various kinds of gram-negative bacteria, such as Escherichia coli, Pseudomonas aeruginosa, Escherichia coli deputy, Klebsiella pneumoniae, acidophilus, Bordetella pertussis and Shigella dysentery.
It is mainly applied to the treatment of infection in wounds, the urinary tract, eyes, ears, and bronchus caused by Pseudomonas aeruginosa and other kinds of pseudomonas. It can also be applied for treating sepsis, peritonitis, and severe infection caused by aminoglycoside-resistant, third generation cephalosporins-resistant bacteria and Pseudomonas aeruginosa or other sensitive strains, such as bacteremia, endocarditis, pneumonia, and burn infection.
Items | Specification | Result |
Appearance | White to almost white powder | Complies |
Identification | A. Liquid chromatographic identification test B. A reddish violet color is produced C. Test for sulfate | Complies |
Loss on drying | ≤7.0% | 3.5% |
PH(2%) | 5.0-7.0 | 6.6 |
Phenylalanine | 9.0%~12.0% | 11.0% |
Sulphated ash | ≤0.75% | 0.01% |
Specific optical rotation | -78°~-90° | -65.6° |
Sulphate | 15.5%~17.5% | 16.0% |
Heavy metal | ≤20ppm | Complies |
Assay(microbial) (on dried basis) | ≥6500iu/mg | 8063iu/mg |
Particle size | 99.0% not more than 30um by vol. 90.0% not more than 25um by vol. 75.0% not more than 20um by vol. Mean diameter not more than 8.0um. | <20 <20 |
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