Name | PI3K/mTOR Inhibitor-2 |
Description | PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16.1, and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, and mTOR, respectively. PI3K/mTOR Inhibitor-2 demonstrates antitumor activity. |
In vitro | PI3K/mTOR Inhibitor-2 exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation with IC50s of 11.6 and 89.2 nM in cell assays, and good pharmacokinetic profile[1]. |
In vivo | PI3K/mTOR Inhibitor-2 demonstrated in vivo efficacy in a PC-3M tumor xenograft model[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 55 mg/mL (114.86 mM), Sonication is recommended.
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Keywords | PI3K | inhibit | Inhibitor | mTOR | PI-3K/mTOR Inhibitor-2 | PI3K/mTOR Inhibitor2 | PI3K/mTOR Inhibitor 2 | Mammalian target of Rapamycin | PI3K/mTOR Inhibitor-2 | Phosphoinositide 3-kinase |
Inhibitors Related | L-Leucine | Capivasertib | Myricetin | Erucic acid | Sapanisertib | (2S,3R,4S)-4-Hydroxyisoleucine | Duvelisib (R enantiomer) hydrochloride | Isoprenaline hydrochloride | Quercetin | Quercetin Dihydrate | Rapamycin | Apilimod |
Related Compound Libraries | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Metabolism Compound Library | Pyroptosis Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |