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PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1].

PI3Kα: 3.4 nM (IC₅₀); PI3Kβ: 34 nM (IC₅₀); PI3Kδ: 16 nM (IC₅₀); PI3Kγ: 1 nM (IC₅₀); mTOR: 4.7 nM (IC₅₀)

[1] Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261. DOI:10.1021/acsmedchemlett.8b00002