Basic information Chemical Properties Uses Indications and Usage Mechanisms of Action Side Effects Carcinogenicity Synthesis of Phenacetin Safety Related Supplier

ChemicalBook Product Catalog Organic Chemistry Amides Amides Phenacetin

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Phenacetin

$ 10.00 /1kg

Min. Order1kg
Purity99.99%
Cas No62-44-2
Supply Ability1ton
Update time2022-11-05

Hebei Shanghai Mifa Trading Co., Ltd

Hebei Shanghai Mifa Trading Co., Ltd

3YR

China

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Chemical Properties

Product Name	Phenacetin
CAS No	62-44-2
EC-No	200-001-8
Min. Order	1kg
Purity	99.99%
Supply Ability	1ton
Release date	2022/11/05

CAS Number	62-44-2	Molecular Weight	179.216
Density	1.0±0.1 g/cm3	Boiling Point	323.6±44.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₃NO₂	Melting Point	133-136 °C(lit.)
MSDS	Chinese USA	Flash Point	149.5±28.4 °C
Symbol	GHS07, GHS08	Signal Word	Danger

Description	Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.Target: COXPhenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and laboratory data were compatible with "phenacetin nephritis" as described in Europe and Australia and recently in the United States and Canada. This report evaluates the findings in the 23 cases and cautions against the use of phenacetin, particularly in patients with impaired renal function [1]. Phenacetin has been linked to renal papillary necrosis in human beings [2, 3].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	COX-3:102 μM (IC50)
Solvent	In Vitro: 10 mM in DMSO
Solubility	1 mM5.5797 mL27.8987 mL55.7973 mL5 mM1.1159 mL5.5797 mL11.1595 mL10 mM0.5580 mL2.7899 mL5.5797 mL
Storage	Powder-20°C3 years 4°C2 yearsIn solvent-80°C6 months -20°C1 month
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	CC(NC1=CC=C(OCC)C=C1)=O
References	[1]. Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31. [2]. Brix, A.E., Renal papillary necrosis. Toxicol Pathol, 2002. 30(6): p. 672-4. [3]. Dubach, U.C., B. Rosner, and T. Sturmer, An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987). N Engl J Med, 1991. 324(3): p. 155-60.
Related Molecules	4-Acetamidophenol \| Aspirin \| Paradol \| Ginsenoside Rg3 \| Ginsenoside C-K \| Xanthohumol \| Ibuprofen \| Diclofenac \| NS-398 \| Meloxicam \| Flufenamic Acid \| (-)-Epicatechin \| Salicylic acid \| ketoprofen \| Naproxen

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	323.6±44.0 °C at 760 mmHg
Melting Point	133-136 °C(lit.)
Molecular Formula	C₁₀H₁₃NO₂
Molecular Weight	179.216
Flash Point	149.5±28.4 °C
Exact Mass	179.094635
PSA	38.33000
LogP	2.01
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.506
Stability	Stable. Incompatible with strong oxidizing agents, strong acids.
Water Solubility	0.076 g/100 mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AM4375000

CHEMICAL NAME :
p-Acetophenetidide

CAS REGISTRY NUMBER :
62-44-2

BEILSTEIN REFERENCE NO. :
1869238

LAST UPDATED :
199709

DATA ITEMS CITED :
77

MOLECULAR FORMULA :
C10-H13-N-O2

MOLECULAR WEIGHT :
179.24

WISWESSER LINE NOTATION :
2OR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Unreported

SPECIES OBSERVED :
Human - man

DOSE/DURATION :
74 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
3600 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
634 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
866 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
33900 mg/m3

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
540 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
1625 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
260 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
2500 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
1 gm/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
1870 mg/kg

TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - hamster

DOSE/DURATION :
1690 mg/kg

TOXIC EFFECTS :
Behavioral - ataxia Behavioral - coma Cardiac - pulse rate increase, without fall in BP

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
10 gm/kg/4W-I

TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
190 mg/m3/4H/30D-I

TOXIC EFFECTS :
Behavioral - alteration of classical conditioning Liver - liver function tests impaired

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
15 mg/m3/4H/17W-I

TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Kidney, Ureter, Bladder - proteinuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
16 gm/kg/43W-C

TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - cat

DOSE/DURATION :
5625 mg/kg/9W-I

TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - woman

DOSE/DURATION :
80 gm/kg/63Y-I

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - man

DOSE/DURATION :
57 gm/kg/47Y-I

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human

DOSE/DURATION :
7300 mg/kg/Y-C

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
572 gm/kg/60W-C

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
1008 gm/kg/96W-C

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
19200 mg/kg/24W-I

TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :
TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
484 gm/kg/96W-C

TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :
TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - man

DOSE/DURATION :
27 gm/kg/10Y-I

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :
TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
9450 mg/kg/45W-C

TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :
TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
206 gm/kg/2Y-C

TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Skin and Appendages - tumors

TYPE OF TEST :
TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human

DOSE/DURATION :
28 gm/kg/28Y-I

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :
TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - man

DOSE/DURATION :
126 gm/kg/25Y-I

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :
TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human - woman

DOSE/DURATION :
140 gm/kg/13Y-I

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
50336 mg/kg

SEX/DURATION :
male 17 week(s) pre-mating

TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
24 gm/kg

SEX/DURATION :
female 1-20 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
6 gm/kg

SEX/DURATION :
female 1-20 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
62920 mg/kg

SEX/DURATION :
male 22 week(s) pre-mating

TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
57200 mg/kg

SEX/DURATION :
male 20 week(s) pre-mating

TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :
Micronucleus test

TYPE OF TEST :
DNA damage

TYPE OF TEST :
DNA damage

TYPE OF TEST :
Cytogenetic analysis

TYPE OF TEST :
Micronucleus test

TYPE OF TEST :
Micronucleus test

TYPE OF TEST :
DNA damage

TYPE OF TEST :
DNA inhibition

TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange

TEST SYSTEM :
Rodent - hamster Lung

DOSE/DURATION :
100 mg/L

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