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Phenacetin is a non-opioid analgesic without anti-inflammatory
properties, inhibits COX-3 activity.Target: COXPhenacetin is a
pain-relieving and fever-reducing drug, Phenacetin was withdrawn from
the Canadian market in June 1973 due to concerns regarding nephropathy.
the clinical and laboratory data were compatible with "phenacetin
nephritis" as described in Europe and Australia and recently in the
United States and Canada. This report evaluates the findings in the 23
cases and cautions against the use of phenacetin, particularly in
patients with impaired renal function [1]. Phenacetin has been linked to
renal papillary necrosis in human beings [2, 3].
| Description |
Phenacetin is a non-opioid analgesic without anti-inflammatory
properties, inhibits COX-3 activity.Target: COXPhenacetin is a
pain-relieving and fever-reducing drug, Phenacetin was withdrawn from
the Canadian market in June 1973 due to concerns regarding nephropathy.
the clinical and laboratory data were compatible with "phenacetin
nephritis" as described in Europe and Australia and recently in the
United States and Canada. This report evaluates the findings in the 23
cases and cautions against the use of phenacetin, particularly in
patients with impaired renal function [1]. Phenacetin has been linked to
renal papillary necrosis in human beings [2, 3]. |
|---|
| Related Catalog |
Research Areas >>
Inflammation/Immunology
|
| Target |
COX-3:102 μM (IC50)
|
| Solvent |
In Vitro: 10 mM in DMSO
|
| Solubility |
1 mM5.5797 mL27.8987 mL55.7973 mL5 mM1.1159 mL5.5797 mL11.1595 mL10 mM0.5580 mL2.7899 mL5.5797 mL
|
| Storage |
Powder-20°C3 years 4°C2 yearsIn solvent-80°C6 months -20°C1 month
|
| Shipping |
Room temperature in continental US; may vary elsewhere
|
| SMILES |
CC(NC1=CC=C(OCC)C=C1)=O
|
Shanghai Mifa chemical Co., Ltd. is a scientific and technological company engaged in the development, production and operation of chemical products. It is a comprehensive enterprise integrating scientific and Technological Development and mass production. It is a professional product R & D and production factory in Shanghai Province, with good product quality.
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