| Name | Parecoxib |
| Description | Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor. |
| In vivo | Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 2 mg/mL (5.4 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 50 mg/mL (134.98 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.4 mM), Sonication is recommended.
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| Keywords | SC-69124 | SC69124 | rheumatoid arthritis | postoperative | POCD | Parecoxib | pain | osteoarthritis | Inhibitor | inhibit | Cyclooxygenase | coxibs | COX-2 | COX | cognitive dysfunction | chronic inflammatory condition | analgesia |
| Inhibitors Related | Acetaminophen | Phenidone | Deferiprone | 4-Aminosalicylic acid | Gallic Acid Monohydrate | Diclofenac Potassium | Paradol | Trometamol | 5-Methylfurfural | Phenylbutazone | Revaprazan hydrochloride | Magnesium sulfate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Anti-Cancer Drug Library |
United States
