198470-84-7

123-62-6

181695-72-7

198470-84-7

General procedure for the synthesis of N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide from propionic anhydride and 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide: 3.1 grams (10 mmol) of 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide was mixed with 3.5 grams (35 mmol) of triethylamine and 2.6 g (20 mmol) propionic anhydride in 20 mL of chloromethane. After completion of the reaction, the reaction mixture was poured into water and extracted with dichloromethane. The extract was concentrated, dissolved in ethanol, crystallized 5 to 10 times, filtered and dried to give 3.4 g of N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide in 92.5% yield and 99.77% purity.