| Name | Pancuronium dibromide |
| Description | Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing with acetylcholine for receptor sites on the motor end-plate. |
| In vitro | Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine, characterized by decrease of the time constant of current decay. Pancuronium also results in competitive block of embryonic-type nicotinic acetylcholine receptor channels. [1] Pancuronium increases heart rate, vecuronium and rocuronium produces positive inotropic effects, and vecuronium shortens refractoriness in isolated rat atria. [2] Pancuronium (0.5 mM) induces a complete fade of the tetanic contraction while leaving the twitch unaffected in the extensor digitorum longus muscle of the rat. Pancuronium decreases the amplitude and increases the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz in the extensor digitorum longus muscle of the rat.[3] |
| In vivo | Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in high dosedogs by 82%. Pancuroniumdecreases tidal volume (VT) and minute ventilation (VE) in low dosedogs by 40% and 55%. [4] Pancuronium limitscerebralhyperemia during prolongedseizuresby attenuating increases inbloodpressure as a result of elimination of skeletal muscle activity in newborn pigs. [5] Pancuroniumresults in a significant difference with control is observed at gallamine concentrations ranging from 0.032-0.32 mM intrachealsmooth musclestrips fromguinea-pigs.[6] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 136.49 mM
DMSO : 60 mg/mL (81.89 mM)
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| Keywords | Nicotinic acetylcholine receptors | noradrenaline | Pancuronium Dibromide | inhibit | neuromuscular | nAChR | Inhibitor | sympathomimetic | Pancuronium | relaxant | Pancuronium dibromide | Steroid | Pancuronium Bromide | skeletal |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Arecoline hydrobromide | Forskolin | CLOZAPINE N-OXIDE | Pilocarpine nitrate | Ribavirin | Adenine | Choline chloride | Propoxur |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Human Metabolite Library |
United States
