| Name | PACAP 1-38 acetate |
| Description | PACAP 1-38 acetate is a pituitary adenylate cyclase activating polypeptide (PACAP) analogue. PACAP 1-38 acetate binds to PACAP type I receptor(IC50 = 4 nM) and PACAP type II VIP2 receptor(IC50 = 1 nM) but not to PACAP type II, VIP1 receptor. |
| In vitro | The ability of neuropeptides to modulate enteric smooth muscle proliferation was examined in primary explant cultures of rabbit gastric antrum and colon smooth muscle. Cell proliferation was determined by [3H]thymidine incorporation measurements and cell counting. PACAP 1-38 acetate concentration dependently (10(-10)M to 10(-6)M) inhibited the serum-induced [3H]thymidine incorporation [in colon, 55.6 +/- 9.3% of control with 10(-7)M PACAP 1-38 acetate] and inhibited increase in cell numbers in cultures derived from the colon but not in those from the antrum. Effects of PACAP 1-38 acetate were mimicked by forskolin (10(-7) to 10(-6) M) but not by 8-bromo-cGMP. Substance P, motilin, calcitonin gene-related peptide, and somatostatin had no effect[3]. |
| In vivo | The effect on total pulmonary resistance (R1) was examined for inhaled PACAP 1-38 acetate in anesthetized, ventilated guinea pigs. Two minutes after inhalation, PACAP 1-38 acetate (36 +/- 6%) inhibited the increase in R1 (% inhibition of histamine-induced R1 prior to inhalation) caused by histamine i.v., whereas the vehicle (-1 +/- 10%) did not. The inhaled peptides caused no sustained effects on heart rate or blood pressure. Infusion of PACAP 1-38 acetate i.v. dose-dependently inhibited the increase in R1 caused by inhaled histamine and by carbachol i.v.[4]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 100 mg/mL, Sonication is recommended.
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| Keywords | PACAP type I | PACAP 1-38 Acetate | PACAP 138 acetate | PACAP 1 38 acetate |
| Inhibitors Related | PACAP (6-38), human, ovine, rat acetate | PAC1R antagonist 1 | PACAP-38 (31-38), human, mouse, rat acetate | PACAP-related Peptide (human) (trifluoroacetate salt) | PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) | PACAP (1-27), human, ovine, rat acetate | PACAP-related Peptide (rat) (trifluoroacetate salt) | PA-8 | PACAP (1-38), human, ovine, rat |
| Related Compound Libraries | Peptide Compound Library |
United States
