| Name | PACAP (6-38), human, ovine, rat acetate |
| Description | PACAP (6-38), human, ovine, rat acetate is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively. |
| In vitro | An increase of dopamine (DA) content by HPLC analysis and/or cell proliferation identified by MTT assay by Dexamethasone (DEX) is also observed which can be inhibited by PACAP (6-38) at concentration sufficient to block PACAP type 1 (PAC1) receptor. Pretreatment with PACAP (6-38) at 0.1 or 1 μM for 2 h significantly blocks this increase of DA content by 1 μM DEX. The MTT assay shows that DEX increases cell proliferation. Moreover, this action is also inhibited by the pre-incubation of PACAP (6-38). PACAP (6-38) at 1μM shows no effect on DA content and cell proliferation for 24 h. However, PACAP (6-38) at 0.3 μM has been mentioned to reduce the spontaneous tyrosine hydroxylase (TH) accumulation in differentiated retinal cultured cells for 5 days[2]. |
| In vivo | Intravesical administration of PACAP (6-38) (300 nM) significantly (p≤0.01) increases intercontraction interval (2.0-fold) and void volume (2.5-fold) in NGF-OE mice. Intravesical instillation of PACAP (6-38) also decreases baseline bladder pressure in NGF-OE mice. Intravesical administration of PACAP (6-38) (300 nM) significantly (p≤0.01) reduces pelvic sensitivity in NGF-OE mice but is without effect in WT mice[3]. |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 50 mg/mL (12.24 mM), Sonication is recommended.
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| Keywords | PACAP type I | PACAP , human, ovine, rat Acetate | PACAP (638), human, ovine, rat acetate(143748189 Free base) | PACAP (6 38), human, ovine, rat acetate(143748 18 9 Free base) |
| Inhibitors Related | PACAP 1-38 acetate | PAC1R antagonist 1 | PACAP-38 (16-38), human, mouse, rat | PACAP-38 (31-38), human, mouse, rat acetate | PACAP (1-38), human, ovine, rat TFA | VIP(Guinea pig) | PACAP (1-27), human, ovine, rat TFA | Thielocin B1 | PACAP (1-27), human, ovine, rat acetate | PACAP-related Peptide (rat) (trifluoroacetate salt) | PA-8 | PACAP (1-38), human, ovine, rat |
| Related Compound Libraries | Peptide Compound Library |
United States
