名称 | p-Cresyl sulfate |
描述 | p-Cresyl Sulfate is the major uremic toxin present in the blood of patients with chronic kidney disease and is derived from the metabolites of tyrosine and phenylalanine in the liver. |
体外活性 | METHODS: H9C2 cardiomyocytes were treated with p-Cresyl Sulfate (3.125, 6.25, 12.5, 25.0 μg/mL) to study the changes in cell proliferation, cell size and mitochondrial parameters, including morphology, respiration, biogenesis and membrane potential.
RESULTS The lowest effective dose of p-Cresyl Sulfate (6.25 μg/mL) induced mitochondrial hypertransfusion, enhanced mitochondrial connectivity, increased mitochondrial oxygen consumption rate, mitochondrial mass, mitochondrial DNA copy number and cardiomyocyte volume; at the same time, p-Cresyl Sulfate increased the phosphorylation of energy-sensing adenosine monophosphate-activated protein kinase (AMPK), but did not induce cell apoptosis. [2] |
体内活性 | METHODS: Mice with AKI induced by ischemia and reperfusion (IR) injury were treated with p-Cresyl Sulfate (20, 40, or 60 mg/L/day for 15 days) to evaluate the effects of p-Cresyl Sulfate administration on renal and cardiac function.
RESULTS p-Cresyl Sulfate at a dose of 20 mg/L resulted in decreased renal mass, increased cystatin C and kidney injury molecule 1 (KIM-1) gene expression, and decreased α-actin in the heart. [3] |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 55 mg/ml (292.24 mM)
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关键字 | pCresyl sulfate | p-Cresyl | p-Tolyl | inhibit | p-Cresyl Sulfate | Endogenous Metabolite | p Cresyl sulfate | Inhibitor |
相关库 | 经典已知活性库 | 天然产物库 | 抗心血管疾病化合物库 | NO PAINS 化合物库 | 高通量筛选天然产物库 | 人内源代谢化合物库 Plus | 已知活性化合物库 | 人代谢物化合物库 |