Oxantel Pamoate NEW

Oxantel Pamoate is a salt complex combining the anthelmintic agent oxantel with pamoic acid (embonic acid). Below is its chemical profile:

Key Chemical Details:

Components:

• Oxantel: A meta-oxyphenol derivative of pyrantel (C₁₁H₁₄N₂O).

• Pamoate: Divalent anion from pamoic acid (C₂₃H₁₆O₆).

  Formula:

• (C₁₁H₁₅N₂O)⁺·(C₂₃H₁₅O₆)⁻

• Molecular weight: ~603 g/mol.

  Structure:

• Oxantel: Contains methyl-pyridyl + hydroxyphenyl groups.

• Pamoate: Two naphthol rings linked via methylene bridge.

Mechanism & Use:

• Anthelmintic: Specifically targets whipworm (Trichuris trichiura).

• Action: Depolarizes nematode muscles → paralysis (nicotinic receptor agonist).

• Poor absorption: Acts locally in the gut (pamoate ensures slow release).

Clinical Formulation:

• Combination therapy: Paired with pyrantel pamoate or albendazole for broad-spectrum deworming.

• Dose: Typically 15–30 mg/kg (single oral dose).

Safety:

• Low systemic toxicity (GI side effects: nausea, abdominal pain).

≤100-word Summary:

Oxantel Pamoate is an anthelmintic salt formed between oxantel (a cholinergic agonist) and pamoic acid. Its structure leverages pamoate’s insolubility to localize action in the intestines. Specifically effective against whipworm infections, it paralyzes worms by activating nicotinic receptors. Used orally in combination therapies (e.g., with pyrantel) for soil-transmitted helminths. Advantages include minimal absorption (<10%) and low systemic toxicity. Common brands include Quantrel Plus®. Molecular weight: ~603 g/mol.