Octreotide acetate

Chemical Name：Octreotide acetate

CAS:83150-76-9

Molecular Formula：C₄₉H₆₆N₁₀O₁₀S₂·C₂H₄O₂

Molecular Weight:1019.24 g/mol (free base: 931.61 g/mol)

Appearance:White or almost white powder

Solubility:Freely soluble in water; slightly soluble in ethanol

Stability:Stable at 2–8°C; protect from light and moisture

Mode of Action:Synthetic somatostatin analog; binds to somatostatin receptors (SSTR2/SSTR5) to inhibit growth hormone, glucagon, and insulin secretion.

Pharmacological Use:Treatment of acromegaly, neuroendocrine tumors (e.g., carcinoid syndrome), and esophageal varices bleeding.

Half-life:1.5–2 hours (subcutaneous); prolonged-release formulations available

Octreotide acetate is a synthetic analog of somatostatin with prolonged activity and selective binding to SSTR2/SSTR5 receptors. Its clinical applications include:

Acromegaly: Suppresses growth hormone secretion.

Neuroendocrine Tumors: Controls symptoms (e.g., flushing/diarrhea in carcinoid syndrome).

GI Bleeding: Reduces portal hypertension in esophageal varices.

Advantages over Somatostatin:

Longer half-life (allows 2–3 daily SC injections or monthly depot formulations).

Higher specificity for target receptors.