| Name | Nicotinamide |
| Description | Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra. |
| In vitro | METHODS: A375, SK-MEL-28, and mouse B16-F10 cells were treated with Nicotinamide (0, 1, 20, and 50 mM) for 24 or 48 hours.
RESULTS: Nicotinamide reduced cell numbers ina dose-dependent manner, with a strong inhibitory effect at 20mM and almost full effect at 50mM. [1] |
| In vivo | METHODS: To study the anti-tumor activity of Nicotinamide, mice were intraperitoneally injected with Nicotinamide (1500 and 1800 mg/Kg, 5 days a week).
RESULTS: Nicotinamide inhibited tumor growth ina mouse model of metastatic melanoma. [1]
METHODS: To study the antiviral activity of Nicotinamide, Nicotinamide (0-200 mg/kg, 5 days) was intraperitoneally injected into HBV transgenic mice.
RESULTS: Nicotinamide inhibited HBV replication in HBV transgenic mice. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 260 mg/mL (2129.05 mM), Sonication is recommended.
Ethanol : 23 mg/mL (188.34 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (40.94 mM), Sonication is recommended.
H2O : 122.7 mg/mL (1004.75 mM), Sonication is recommended.
|
| Keywords | skin cancer | Sirtuin | SIRT | Nicotinamide | Murine metastatic melanoma model | Melanoma | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | A375 cell |
| Inhibitors Related | Sucrose | Aceglutamide | Emtricitabine | 3-Hydroxybutyric acid sodium | Levulinic acid | D(+)-Raffinose pentahydrate | D-(+)-Trehalose dihydrate | Glycerol | Thymidine | Sodium 2-hydroxybutanoate | Chitosan oligosaccharide | 3-Indoleacetic acid |
| Related Compound Libraries | Drug Repurposing Compound Library | Cosmetic Ingredient Compound Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Gut Microbial Metabolite Library |
United States
