| Name | NG,NG-dimethyl-L-Arginine dihydrochloride |
| Description | NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to the regulation of blood pressure and to host defence[1]. |
| In vitro | NG,NG-dimethyl-L-Arginine (ADMA) was found to be able to inhibit macrophage and vascular NO synthase. When added to a cytosolic preparation of macrophage NO synthase, ADMA could cause dose-dependent inhibition of NO formation. In the presence of added arginine, ADMA could inhibited NO synthesis and the inhibitory effects of ADMA were prevented by addition of L-arginine so that the rate of NO synthesis did not significantly differ from control values [1]. |
| In vivo | Animal study showed that the injection of 1-30 mg/kg ADMA into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. Moreover, during continuous infusion of ADMA, which caused plasma ADMA concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 11 mg/mL (39.97 mM), Sonication is recommended.
DMSO : 7 mg/mL (25.44 mM), Sonication is recommended.
H2O : 14 mg/mL (50.88 mM), Sonication is recommended.
|
| Keywords | NOSynthase | NO Synthase | nitric oxide | NG,NG-dimethyl-L-Arginine Dihydrochloride | NG,NGdimethylLArginine dihydrochloride | NG,NG-dimethyl-L-Arginine | NG,NG dimethyl L Arginine dihydrochloride |
| Inhibitors Related | Aminoguanidine hydrochloride | L-NAME hydrochloride | Mifepristone | 2,4-Diamino-6-hydroxypyrimidine | S-Methylisothiourea sulfate | L-Arginine | Nitroarginine | 1400W dihydrochloride | Ethyl cinnamate | Methylene Blue | Methylene Blue trihydrate | L-Arginine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Neuroprotective Compound Library | Inhibitor Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
