| Name | L-Arginine hydrochloride |
| Description | L-Arginine hydrochloride serve as substrates and nitrogen donors for endothelial nitric oxide synthase (eNOS) to produce nitric oxide (NO). They are transported into vascular smooth muscle cells via cationic amino acid transporters, where they are metabolized into NO, polyamines, or L-proline. As effective vasodilators, they are commonly used to induce experimental acute pancreatitis models. |
| In vitro | In individuals with sickle cell anemia, oral administration of L-Arginine (0.1 g/kg) significantly reduces pulmonary arterial systolic pressure after 5 days. Continuous treatment with L-Arginine (4 mg/kg per minute for 1 hour) in rabbit limbs subjected to regional ischemia/reperfusion reduced superoxide production by cNOS, thereby increasing NO accumulation. In SV-129 mice, subcutaneous injection of L-Arginine (2 mg/kg) resulted in the upregulation of eNOS. |
| In vivo | Treatment with L-Arginine (0.3 mM) for 30 minutes significantly increases nitric oxide (NO) production in bovine aortic endothelial cells exposed to n-LDL and oxidized-LDL. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 10 mM, Sonication is recommended.
DMSO : Insoluble
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| Keywords | NOSynthase | NOS | NO Synthase | Nitric oxide synthases | L-arginine Monohydrochloride | L-Arginine Hydrochloride | LArginine hydrochloride | L-Arginine HCl | L-arginine | L-Arginine | L-Arg | L Arginine hydrochloride | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Arginine Hydrochloride | AminoAcidsandDerivatives | Amino Acids and Derivatives |
| Inhibitors Related | Sucrose | Cysteamine hydrochloride | Acetaminophen | Daidzein | Fumaric acid | Guanidine hydrochloride | Ferulic Acid | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Natural Product Library | Drug Repurposing Compound Library | Miao medicine Compound Library | Microbial Natural Product Library | Neuroprotective Compound Library | Human Endogenous Metabolite Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
