| Name | Neohesperidin Dihydrochalcone |
| Description | Neohesperidin Dihydrochalcone (Neohesperidin DC) is an artificial sweetener derived from citrus. |
| Cell Research | WST-8 dye is used in the cell viability assay. HIT-T15 and HUVEC cells are grown and maintained in Dulbecco's modified Eagle's medium, supplemented with 10% fetal bovine calf serum. 1000 cells in each well are incubated with various concentrations of neohesperidin dihydrochalcone (50, 100, 500 μM, 1 mM) and other compounds. After treating HIT-T15 and HUVEC cells with 500 μM HOCl, WST-8 dye is added to each well, and the absorbance is detected at 420 nm with microplate reader[1]. |
| In vivo | Administration of neohesperidin dihydrochalcone significantly reduces the activities of AST and ALT, both key markers of liver damage. It also inhibits the expression of NF-κB, IL-6, IL-1β, and TNF-α proteins, which are elevated in the liver of PQ-treated mice, indicating its potential protective effects on liver inflammation and damage[3]. Furthermore, studies on Wistar Crl:(WI)WU BR rats to assess the embryotoxicity and teratogenicity of neohesperidin dihydrochalcone reveal no adverse effects at dietary levels up to 5%, the highest dose investigated. At this level, rats consumed approximately 3.3 g/kg body weight/day[4], demonstrating the compound's safety at significant dosage levels. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 100 mg/mL (163.24 mM)
DMSO : 50 mg/mL (81.62 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Neohesperidin Dihydrochalcone | Reactive Oxygen Species | Inhibitor | inhibit |
| Inhibitors Related | Imeglimin hydrochloride | Acetylcysteine | L-Ascorbic acid |
| Related Compound Libraries | Flavonoid Natural Product Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library |
United States
