Description
N-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder. It is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort. It has found that it can regulate tumor stem cell genes EZH2/AXL and reduced its migration and invasion in glioblastoma. Moreover, it can induce apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2a and telomerase activity. Therefore, it is a potential cancer chemotherapy drug. Moreover, It can also exhibit protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3. Finally, it has certain antiplatelet effect.
| Product Name: | N-BUTYLIDENEPHTHALIDE |
| Synonyms: | N-BUTYLIDENEPHTHALIDE;3-BUTYLIDENEPHTHALIDE;FEMA 3333;BUTYLIDENE PHTHALIDE;1(3H)-Isobenzofuranone,3-butylidene-;3-butylidene-1(3h)-isobenzofuranon;3-butylidene-1(3H)-Isobenzofuranone;3-butylidene-phthalid |
| CAS: | 551-08-6 |
| MF: | C12H12O2 |
| MW: | 188.22 |
| EINECS: | 208-991-3 |
| Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;Phthalides;A-B;Alphabetical Listings;Flavors and Fragrances;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 551-08-6.mol |
| Melting point | 82.5°C |
| Boiling point | 139-142 °C/5 mmHg (lit.) |
| density | 1.103 g/mL at 25 °C (lit.) |
| FEMA | 3333 | 3-BUTYLIDENEPHTHALIDE |
| refractive index | n20/D 1.577(lit.) |
| Fp | >230 °F |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Oil |
| color | Colourless to Yellow |
Japan
