Chemical Properties
3-Butylidenephthalide has a pervasive warm spicy aroma.
Occurrence
Reported as occurring naturally in the fruits and roots of Ligusticum acutilobum and lovage (Levisticum officinale)
seeds, roots and leaves.
Uses
3-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder.
Definition
ChEBI: A gamma-lactone that is phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits hypoglycemic activity.
Taste threshold values
Taste characteristics at 15 ppm: celery, green, vegetable-like with a herbal nuance.
General Description
3-Butylidenephthalide is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort.
Cytotoxicity
The anti-proliferative effects of 3-Butylidenephthalide (n-Butylidenephthalide; BP) on cells from GBM, neuroblastoma, lung cancer, melanoma, teratoma, leukemia, breast cancer and hepatocellular carcinoma, as well as from normal fibroblast and vascular endothelial cells, were determined. The IC50 values of BP after a 48 h incubation with tumor cell lines (IC50: 15–67 μg/mL) were significantly lower than the values for normal fibroblast cells (IC50: >?100 μg/mL, p < 0.0001) or carmustine (BCNU)-treated tumor cells (IC50: 40 ～ 100 μg/mL, p < 0.001; Table 1). In the two normal cell types, vascular endothelial cells (IC50 = 25.0 ± 2.0 μg/mL) were more sensitive to BP than fibroblast cells (IC50 > 100 μg/mL) (p < 0.0001). These experiments showed that BP could induce high cytotoxicity against brain and other tumour cells but only low or no cytotoxicity against normal fibroblast cells.
target
Nrf2 | TNF-α | NO | IL Receptor
