N-Acetyl-D-Glucosamine CAS:7512-17-6 Pharmaceutical Raw Materials
Product Name:N-Acetyl-D-Glucosamine
Synonyms:N-Acetyl-D-glucosaMine, 98.0%(LC&N;N-qcetyl-D-glucosamine;2-Acetamido-2-deoxy-alpga-D-glucopyranose;D-GLCNAC;ACETYL-D-GLUCOSAMINE, N-;N-ACETYL-DELTA-GLUCOSAMINE;2-ACETAMIDO-2-DESOXY-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE;2-ACETAMIDO-2-DEOXY-D-GLUCOSE
CAS:7512-17-6
MF:C8H15NO6
MW:221.21
EINECS: 231-368-2
Melting point:211 °C (dec.) (lit.)
alpha:42 º (c=2,water,2 hrs)
vapor pressure:8Pa at 20℃
refractive index:+39.0 to +42.0 ° (C=1, H2O)
storage temp.:-20°C
solubility:Soluble in concentrated hydrochloric acid, sulfuric acid, phosphoric acid and formic acid. Insoluble in water, dilute acids, dilute alkalis, concentrated alkalis and organic solvents.
Boiling point:636.4±55.0 °C(Predicted)
density:1.54 g/cm3
Stability:Stable. Incompatible with strong oxidizing agents.
chemical Properties:White powder
Description
N-Acetyl-D-Glucosamine is the N-acetyl derivative of glucosamine.Chemically it is an amide between glucosamine and acetic acid. A single N-acetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins -O-GlcNAc, is an ubiquitous post-translational protein modification. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. In humans, it exists in skin, cartilage and blood vessel as a component of hyaluronic acid, and bone tissue, cornea and aorta as a component of keratan sulfate.
N-Acetyl-D-glucosamine (D-GlcNAc) is a derivitized glucose monomer found in polymers of bacterial cell walls, chitin, hyaluronic acids and various glycans. It is also synthesized in the glycosylation pathway as uridine diphosphate (UDP-GlcNAc), which can then be released following degradation of glycosylated proteins.D-GlcNAc is used to identify, differentiate and characterize N-acetyl-β-D-hexoaminidase(s). It is also used in the treatment of osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. Further, it is used as a substrate in sialic acid production, cosmetics and in drug development research.
China
