Name | Myricitrin |
Description | Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects. |
In vitro | In mice, Myricitrin (10/30 mg/kg, i.p.) blocks apomorphine-induced stereotypy and climbing behaviors, while also prolonging the hindlimb withdrawal time. |
In vivo | In rodent models of chemical and mechanical pain, Flurbiprofen activates protein kinase Cα and PKCε, while Myricitrin blocks this action, thereby exerting a significant analgesic effect. The pain-relief mechanism of Myricitrin is attributed to a decrease in calcium ion influx and the opening of voltage-dependent and small-conductance calcium-activated potassium (K+) channels. Additionally, Myricitrin inhibits the expression of the p53 gene, which leads to the activation of caspase-3 and the MAPK signaling pathway, while altering the expression pattern of anti-apoptotic and pro-apoptotic genes. Consequently, this reduces H₂O₂-induced apoptosis in vascular endothelial cells. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 86 mg/mL (185.2 mM) Ethanol : 1 mg/mL (2.15 mM)
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Keywords | antioxidant | Inhibitor | inhibit | Myricitrin |
Inhibitors Related | Ellagic acid | α-Vitamin E | Ro-3306 | Staurosporine | Methyl-Hesperidin | N-Desmethyltamoxifen hydrochloride | Fasudil hydrochloride | Mitoxantrone dihydrochloride | DCPLA-ME | R59949 |
Related Compound Libraries | Anti-Tumor Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | TGF-beta/Smad Compound Library |