| Name | Se-Methylselenocysteine |
| Description | Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis. |
| In vitro | Se-Methylselenocysteine displayed strong inhibitory effects on cell proliferation and viability of SKOV-3 cells in dose and time dependent manners and induced apoptosis. Pretreatment of cells with the caspase inhibitors (z-VAD-fmk and DEVD-CHO) prevented Se-Methylselenocysteine-induced apoptosis. In late stage of apoptosis, p18kDa fragment of Bax was generated with the down-regulation of the expressions of survivin, X-linked inhibitor of apoptosis protein, and human inhibitor of apoptosis protein 1 following Se-Methylselenocysteine treatment. Pre-treatments of z-VAD-fmk and the calpain inhibitor, calpeptin inhibited Bax cleavage. Taken together, the chemopreventive effects of Se-Methylselenocysteine may be related in part to the caspase-3 activation, the down-regulation of IAP family proteins, and Bax cleavage mediated by caspase-dependent calpain activation[2]. |
| In vivo | AD mice are treated with Se-Methylselenocysteine (0.75 mg kg-1 BW per day) in their drinking water for 10 months. Results reveal that Se-Methylselenocysteine 1) reduces oxidative stress and neuro-inflammation; 2) modulates the distribution and levels of several metal ions; 3) decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1); and 4) attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice[4]. |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 83.33 mg/mL (457.66 mM)
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| Keywords | caspase-3 | A253 | neck | Apoptosis | chemopreventive | cancer | Se-Methylselenocysteine | Inhibitor | SeMethylselenocysteine | Methylselenocysteine | inhibit | Se Methylselenocysteine | orally | head | cells | FaDu | SKOV-33 |
| Inhibitors Related | Taurodeoxycholic acid | (S)-(+)-Ibuprofen | SKLB-163 | Navitoclax | Gossypol | Taurochenodeoxycholic Acid | Tauroursodeoxycholate sodium | Lisaftoclax | Venetoclax | (Iso)-Z-VAD(OMe)-FMK | Tauroursodeoxycholate | Boc-Asp(OMe)-fluoromethyl ketone |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Natural Product Library | Microbial Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max | Food as Medicine Compound Library | Anti-Cancer Drug Library |
United States
