| CAS: | 30233-64-8 |
| MF: | C25H50O4 |
| MW: | 414.66 |
| EINECS: | 250-097-0 |
| Product Categories: |
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| Mol File: | 30233-64-8.mol |
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| MONOBEHENIN Chemical Properties |
| density | 0.93[at 20℃] |
| vapor pressure | 0.001Pa at 25℃ |
| solubility | Soluble, when heated, in chloroform and dichloromethane and in many organic solvents; slightly soluble in hot ethanol (96%); practically insoluble in cold ethanol (95%), hexane, mineral oil, and water. |
| form | A solid |
| Water Solubility | 100ng/L at 25℃ |
| LogP | 8.58 at 25℃ |
| EPA Substance Registry System | Docosanoic acid, monoester with 1,2,3-propanetriol (30233-64-8) |
| MONOBEHENIN Usage And Synthesis |
| Chemical Properties | Glyceryl behenate occurs as a fine white-yellow powder, as a hard waxy mass or pellet, or as white or almost white unctuous flakes. It has a faint odor. |
| Production Methods | Glyceryl behenate is prepared by the esterification of glycerin by behenic acid (C22 fatty acid) without the use of catalysts. In the case of Compritol 888 ATO (Gattefosse′), raw materials used are of vegetable origin, and the esterified material is atomized by spraycooling. |
| Definition | ChEBI: 1-behenoylglycerol is a fatty acid ester resulting from the formal condensation of the hydroxy group at position-1 of glycerol with the carboxy group of docosanoic acid. It has a role as a plant metabolite and an antineoplastic agent. It is a 1-monoglyceride and a fatty acid ester. It is functionally related to a glycerol and a docosanoic acid. |
| Pharmaceutical Applications | Glyceryl behenate is used in cosmetics, foods, and oral pharmaceutical formulations.
In pharmaceutical formulations, glyceryl behenate is mainly used as a lubricant in the preparation of oral tablets and capsules. It has good binding properties, it does not affect tablet hardness and is unaffected by mixing or production parameters. Glyceryl behenate has been investigated for the encapsulation of various drugs such as retinoids. It has also been investigated for use in the preparation of sustained-release tablets; as a matrix-forming agent for the controlled release of water-soluble drugs; and it can also be used as a hot-melt coating agent sprayed onto a powder or drug-loaded sugar beads and granules. It may also be incorporated via extrusion/spheronization into pellets, which can be further compressed into tablets.
Glyceryl behenate is used in oral enteric-coated pellets, powders and suspensions. It is also used in controlled, extended-release and orally disintegrating tablets. For oral preparations, glyceryl behenate forms a lipidic matrix for sustained-release formulations. It has been used along with acid-soluble or swellable polymers to mask the bitter or unpleasant taste of the medicament with improved palatability.
Glyceryl behenate has been used for the preparation of ophthalmic inserts.
In cosmetics, glyceryl behenate is used as a skin conditioning agent, emollient and viscosity-increasing agent in emulsions. It also improves the heat stability of emulsions and is a gelifying agent for various oils. For topical formulations, it is used as a thickening agent for oily phases. It is also used as a surfactant or emulsifying agent. |
| Safety | Glyceryl behenate is used in cosmetics, foods and oral pharmaceutical formulations, and is generally regarded as a relatively nonirritant and nontoxic material. The US Cosmetic Ingredients Review Expert Panel evaluated glyceryl behenate and concluded that it is safe for use in cosmetic formulations in present practices of use and concentration.
LD50 (mouse, oral): 5 g/kg |
| storage | Glyceryl behenate should be stored in a tightly closed container, at a temperature less than 35°C. |
| Regulatory Status | GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules, tablets, and suspensions). Included in the Canadian List of Acceptable Non-medicinal Ingredients. |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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