| Name | Minocycline hydrochloride |
| Description | Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochloride can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment. |
| In vitro | Minocycline exhibits significant neuroprotective effects in models of cerebral ischemia, traumatic brain injury, Huntington's disease, and Parkinson's disease. Its neuroprotective properties may involve the inhibition of 5-lipoxygenase (an inflammatory enzyme associated with brain aging). Additionally, Minocycline's activity is linked to the inhibition of protein synthesis. |
| In vivo | Minocycline inhibits the release of cytochrome c mediated by the permeability transition in mitochondria. This inhibition by minocycline on cytochrome c release has been demonstrated in vivo, in cells, and isolated mitochondria. Additionally, minocycline suppresses the activity of inducible caspase-1 and caspase-3, inducible nitric oxide synthase (iNOS), and p38 mitogen-activated protein kinase (MAPK). Following experimental focal ischemia, minocycline reduces the upregulation of caspase-1 and iNOS, thereby decreasing infarct size. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 12.4 mg/mL (25 mM)
DMSO : 60 mg/mL (121.47 mM)
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| Keywords | Antibiotic | Calcium Channel | Inhibitor | HIF-PH | Myocardial ischemia | MDM-2/p53 | PI3K/Akt | Apoptosis | Potassium Channel | inhibit | Ca2+ channels | Hypoxia-inducible factors | HIFs | infection | L-type Ca2+ channel | Minocycline hydrochloride | stroke | cerebral ischemia | HIF/HIF Prolyl-Hydroxylase | Ca channels | acinetobacter | neuroprotective | Minocycline | Minocycline Hydrochloride | KcsA | ovarian cancer | Mitochondrial ATP-sensitive potassium | Ventricular arrhythmia | Bacterial |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Hydroxycitric acid tripotassium hydrate | EDTA copper(II) disodium salt | Dimethyl sulfoxide | Crystal Violet |
| Related Compound Libraries | Bioactive Compound Library | Approved Drug Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | FDA-Approved Drug Library | Orally Active Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-COVID-19 Compound Library | Anti-Infection Compound Library |
United States
