Melanotan(MT)-IIisapotentnon-selectivemelanocortinreceptoragonistwithhighaffinityforMC1,MC3,MC4,andMC5receptorsubtypeswhichareinvolvedintheregulationChemicalbookofanumberofphysiologicalsystemssuchasthepigmentarysystem,energyhomoeostasis,sexualfunctioning,theimmunesystem,inflammation,andthecardiovascularsystem.
Melanotan(MT)-IIexertsadose-dependentinduceractivityonerectionbyelicitingerectileeventsandshorteninglatencyofthefirsterectileeventtooccur.Erectileresponseselicitedbycavernousnervestimulationareincreasedafteri.v.melanotan(MT)-II(1mg/kg),therebyexertingfacilitatoreffectonerection.Melanotan(MT)-IIpromotesperipheralnerveregenerationandhasneuroprotectivepChemicalbookropertiesintherat.Melanotan(MT)-IIsignificantlyenhancestherecoveryofsensoryfunctionfollowingacrushlesionofthesciaticnerveintheratatadoseof20μg/kgper48h,s.c.,butnotatadoseof2or50μg/kg.Melanotan(MT)-IIisapotentinitiatorofpenileerectioninmenwitherectiledysfunction.Melanotan(MT)-IIreducesfoodintakeandbodyweightandinvokesthermogenicresponsesinamousemodel.
Australia
