| Name | Matrine |
| Description | Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. |
| In vitro | In human non-small cell lung cancer A549 and hepatocellular carcinoma SMMC-7721 cells, Matrine inhibits cell growth. Particularly, in A549 cells, Matrine induces apoptosis by reducing the Bcl-2 / Bax protein ratio. |
| In vivo | In mice, the median lethal dose (LD50) of Matrine administered via intraperitoneal injection is 157 mg/kg. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.05 mM), Sonication is recommended. Ethanol : 49 mg/mL (197.29 mM), Sonication is recommended. H2O : 20 mg/mL (80.53 mM), Sonication is recommended. DMSO : 45 mg/mL (181.19 mM), Sonication is recommended.
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| Keywords | κ-opioid receptor | OpioidReceptor | Opioid Receptor | Non-small cell lung cancer | Mitophagy | Matrine | hepatoma | Ferroptosis | Autophagy | anti-oxidative stress | a-Matrine | alpha-Matrine | acute kidney injury (AKI) model | A549 cells |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Urea | Cysteamine hydrochloride | Hydroxychloroquine | Metronidazole | Guanidine hydrochloride | Paeonol | Naringin | Alginic acid |
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