| Name | Lucideric acid A |
| Description | Lucideric acid A (Lucidenic acid A) is a modulator of JNK and p38 and enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK/MAPKs activation. |
| In vitro | Here, we showed that triterpenes-rich extract of antlered form of G. lucidum (G. lucidum AF) induces TNFα± production in monocytic THP-1 cells. Furthermore, the extract also synergized with lipopolysaccharide (LPS) to induce TNFα± production in THP-1 cells, suggesting an immunostimulatory role of triterpenes-rich extract of G. lucidum AF. Notably, the extract enhanced LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), while it suppressed LPS-induced phosphorylation of c-Jun N-terminal kinase (JNK) MAPK. p38 Inhibitor suppressed TNFα± production, while JNK inhibitor enhanced TNFα± production, implying that synergistic effect of the extract may work by modulating p38 and JNK MAPKs. Moreover, we found that the triterpenes-rich extract of G. lucidum AF contains high amounts of lucidenic acids. Lucidenic acid-A, -F and -D(2), which seem to dominantly exist in the extract, were purified from the triterpenes-rich extract. We also identified Lucidenic acid-A and -F as modulators of JNK and p38, respectively[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (130.84 mM), Sonication is recommended.
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| Keywords | p38MAPK | p38 MAPK | p38 | MMP-9 | MMP | Matrix metalloproteinases | Lucideric acid A | JNK | Inhibitor | inhibit |
| Inhibitors Related | Undecane | Esculin | Bisphenol A | Doxycycline (hyclate) | Chondroitin sulfate | Fumaric acid | Doxycycline | Glucosamine | Anethole | Meloxicam | Propoxur | Metacetamol |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Rare Natural Product Library | Kinase Inhibitor Library | Natural Product Library | Microbial Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Food as Medicine Compound Library |
United States
