Name | LMPTP INHIBITOR 1 dihydrochloride |
Description | LMPTP Inhibitor 1 Dihydrochloride is a compound selectively targeting low molecular weight protein tyrosine phosphatase (LMPTP), exhibiting potent inhibitory activity with an IC50 value of 0.8 μM for LMPTP-A. |
In vitro | LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50?of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 dihydrochloride (10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes[1]. |
In vivo | LMPTP inhibitor 1 dihydrochloride, an orally bioavailable compound, achieves an approximate mean serum concentration of 680 nM following 0.03% w/w administration and exceeds 3 μM with 0.05% w/w dosage. Notably, it reverses diabetes in obese mice. At a concentration of 0.05% w/w, it effectively inhibits LMPTP activity, leading to a significant enhancement in glucose tolerance and a reduction in fasting insulin levels in diabetic DIO mice, with no impact on body weight[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O : 50 mg/mL (96.61 mM), Sonication is recommended. DMSO : 64 mg/mL (123.66 mM)
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Keywords | inhibit | LMPTP inhibitor-1 | LMPTP inhibitor 1 | LMPTP INHIBITOR 1 dihydrochloride | Phosphatase | LMPTP INHIBITOR 1 Dihydrochloride | LMPTP inhibitor1 | Inhibitor | LMPTP INHIBITOR 1 |
Inhibitors Related | PTP1B-IN-22 | Disodium monofluorophosphate | β-Glycerophosphate disodium salt pentahydrate | MLS000544460 | Tartaric acid disodium dihydrate | Cyclosporine | Stearic acid | Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride | L-Ascorbic acid 2-phosphate magnesium | Cyclosporin A | Trimyristin | β-Glycerophosphate disodium salt hydrate |
Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max |