| Name | Litorin |
| Description | Litorin is a bombesin derivative derived from amphibians and acts as a bombesin receptor agonist. It induces smooth muscle contraction, stimulates the secretion of gastrin, gastric acid, and pancreatic juice, and inhibits nutrient uptake in in vivo experiments. |
| In vitro | Methods: The inhibitory effect of [D-Phe¹, Leu⁸,⁹] litorin on receptor binding in mouse Swiss 3T3 cells was determined.
Results: [D-Phe¹, Leu⁸,⁹] litorin inhibited the binding of ¹²⁵I-[Tyr⁴] BN to mouse Swiss 3T3 cells, with a Ki value of 5.1 nM [2].
Methods: The effect of litorin on ³H-thymidine incorporation in mouse Swiss 3T3 cells was examined.
Results: Litorin stimulated ³H-thymidine incorporation in mouse Swiss 3T3 cells, with an EC₅₀ value of 2.3 nM [2]. |
| In vivo | Methods: The application of ⁹⁹ᵐTc-litorin for tumor imaging was developed and evaluated.
Results: ⁹⁹ᵐTc-litorin can be used for noninvasive imaging of tumors with high expression of gastrin-releasing peptide receptor (GRP-R) [1].
Methods: The regulatory effects of litorin on physiological functions related to the gastrointestinal tract and smooth muscle were investigated in vivo.
Results: Litorin stimulated smooth muscle contraction, promoted the secretion of gastrin, gastric acid and pancreatic juice, and inhibited the absorption of nutrients in vivo [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (73.72 mM), Sonication is recommended.
H2O : 1 mg/mL (0.92 mM), Sonication is recommended.
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| Keywords | Litorin |
| Inhibitors Related | Bag-1 | BA 1 acetate(183241-31-8 free base) | ML-18 | Bombesin acetate(31362-50-2 free base) | kuwanon G | Kuwanon H | Litorin acetate(55749-97-8 Free base) | CD80-IN-3 | [D-Phe12]-Bombesin acetate | PD176252 | [D-Phe12,Leu14]-Bombesin acetate | PD 168368 |
United States
