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ChemicalBook Product Catalog Lirequinil

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Lirequinil NEW

$160.00 1mg

$400.00 5mg

$600.00 10mg

Min. Order
Purity98.06%
Cas No143943-73-1
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Lirequinil
CAS No	143943-73-1
EC-No
Min. Order
Purity	98.06%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Lirequinil
Description	Lirequinil (Ro 41-3696) is a small molecule GABAA receptor agonist utilized in the study of neurological disorders.
In vivo	In a double-blind, six-way crossover study of the effects on psychomotor performance and memory of single doses of Ro 41-3696 (Lirequinil) (1, 3, 5, and 10 mg), a novel non-benzodiazepine partial agonist at the benzodiazepine receptor, zolpidem (10 mg) and placebo were compared after night-time administration to 12 healthy young male subjects. Psychomotor performance tests (tracking and attention as part of a standardized task battery) were conducted just before and at 1.5 and 8 h after drug intake. The memory test consisted of the recall of a list of 15 words at 8 h after drug intake which had been learned at 1.5 h after intake. At 1.5 h after drug intake 10 mg zolpidem induced markedly larger psychomotor effects than any dose of Ro 41-3696. The effects of 5 and 10 mg Ro 41-3696 and zolpidem were significantly greater than those of placebo (P < 0.05). The following morning, 8 h after drug intake, the slight residual effects of 5 and 10 mg Ro 41-3696 were statistically significantly greater than placebo, whereas zolpidem effects did not differ from placebo. The results of the memory test showed that learning as well as recall was most clearly impaired by zolpidem. An influence of Ro 41-3696 on these variables was not observed for doses up to 5 mg. In conclusion, Ro 41-3696 at all doses tested induced fewer effects on psychomotor performance and memory than 10 mg zolpidem at 1.5 h after intake. However, the effects of Ro 41-3696 appeared to be of longer duration. [2]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 50 mg/mL (111.37 mM)
Keywords	Lirequinil
Inhibitors Related	Valproic acid sodium salt \| DL-Menthol \| Penicillin G sodium salt \| Valproic Acid \| Halothane \| Chlorothymol \| Piperazine citrate \| Riluzole \| Gabapentin \| (-)-α-Pinene
Related Compound Libraries	Anti-Neurodegenerative Disease Compound Library \| Pain-Related Compound Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Neurotransmitter Receptor Compound Library \| Bioactive Compounds Library Max \| Ion Channel Targeted Library

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