| 名称 | GJ103 sodium salt |
| 描述 | GJ103 sodium salt is an active analog of GJ072, a read-through compound. It has been shown to reduce the surface tension of aqueous solutions, which makes it easier for molecules to move through the solution. It has also been shown to reduce the viscosity of aqueous solutions, which makes it easier for molecules to move through the solution. Additionally, it has been shown to reduce the pH of aqueous solutions, which can have a variety of effects on the biochemical and physiological processes of living organisms. |
| 细胞实验 | Cell proliferation assay is used to measure cytotoxicity. Cells are seeded into a flat-bottom 96-well plate, including control wells containing complete growth medium alone as blank absorbance readings. After RTC treatment (GJ103), activated-XTT Solution is added into each well, and the cells are returned to the cell culture incubator for 12-14 hours. The absorbance is measured at 480 nM with relevant 630 nM to assess nonspecific readings. |
| 体外活性 | GJ072 induces ATM kinase on both TGA and TAG stop codons and restored ATMpSer1981 autophosphorylation and SMC1pSer966 transphosphorylation as measured by FACS. GJ072 is active in A-T cells with a homozygous TAA mutation. GJ072 is able to induce detectable full-length ATM protein in treated A-T cells. Early structure-activity relationship studies generates eight active analogs of GJ072. Some GJ072 analogs (e.g., GJ103, GJ106, GJ109, and GJ111) consistently demonstrates their activities in all three PTCs by both FCATMpSer1981 and IRIF assays. GJ071 and GJ072 and some of their analogs (such as GJ103) have similar read-through activity as RTC13 or RTC14, but are more tolerable than RTC13 and RTC14 to A-T cells. GJ103 does not show obvious cytotoxicity in A-T cells at concentration as high as 300 μM. |
| 体内活性 | GJ103 sodium salt is water soluble, which will enable us to evaluate its in vivo activity by systematic administration. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : Soluble
DMSO : 50 mg/mL (137.23 mM)
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| 关键字 | Inhibitor | GJ103 sodium salt | inhibit | GJ-103 sodium salt | GJ103 sodium | GJ 103 | GJ-103 | GJ103 |
| 相关产品 | CP-466722 | Ro 90-7501 | AZ31 | Dactolisib | Berzosertib | Elimusertib | KU60019 | Ceralasertib | (Z)-Mirin | NU6027 | Schisandrin B | AZ32 |
| 相关库 | PI3K/Akt/mTOR 化合物库 | 抗结直肠癌化合物库 | 经典已知活性库 | 抗抑郁症化合物库 | 激酶抑制剂库 | 抗乳腺癌化合物库 | 抗衰老化合物库 | 已知活性化合物库 | 抗癌化合物库 | 神经元分化化合物库 |
United States
