| Name | Linoleic acid |
| Description | Linoleic acid (9,12-octadecadienoic acid) is a naturally occurring polyunsaturated fatty acid found in animal and vegetable oils. Linoleic acid is an essential fatty acid that is part of membrane phospholipids. |
| In vitro | METHODS: Bovine satellite cell BSCs were treated with Linoleic acid (10-250 µM) for 24-48 h. Cell viability was measured by MTT assay.
RESULTS: At 24 h of treatment with Linoleic acid, cell proliferation increased at doses of 10-100 µM and decreased at 250 µM as compared to untreated control. 100 µM Linoleic acid at 48 h had no significant effect on cell proliferation. [1]
METHODS: Human ovarian cancer cells SKOV-3 were treated with Linoleic acid (16 µM) for 24 h. Cell migration was detected by wound-healing assay.
RESULTS: The average migration in the Linoleic acid treated group increased by about 20% on average compared to control untreated cells. [2] |
| In vivo | METHODS: To study the effects on endocannabinoid (EC) biology, four groups of C57BL/6 mice were fed diets containing 1% or 8% Linoleic acid (with or without G (LAG)) for eight weeks.
RESULTS: Increasing dietary Linoleic acid from 1% to 8% significantly increased circulatory, small intestinal, and hepatic ECS. 1% LAG-fed mice had the lowest feed efficiencies, and hepatic levels of only two ECs were reduced by the addition of G. [3] |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (196.11 mM)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.33 mg/mL (15.44 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
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| Keywords | polyunsaturated | omega-6 | acid | metabolite | arachidonic acid | inhibit | Inhibitor | fatty | Endogenous Metabolite | oils | endogenous | essential | Linoleic acid | nutrient | human | plant |
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