Linaclotide

Product Specifications

Description:

In August 2012, the US FDA approved linaclotide (also referred to as MD-1100), a first-in-class, orally administered 14-amino acid peptide as a therapy for patients suffering from chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Linaclotide and its active metabolite MM-419447, which results from the cleavage of the C-terminal tyrosine residue by carboxypeptidase A, mimic the actions of the endogenous intestinal peptides guanylin (15 amino acids) and uroguanylin (16 amino acids) by activating guanylyl cyclase C (GC-C) on the intestinal epithelium. Activation of GC-C leads to increased intra- and extracellular levels of cGMP and activation of the CFTR ion channel, resulting in increased levels of HCO3-, Cl-, and water in the intestinal lumen and accelerated gastrointestinal transit. Based on an in vitro assaymeasuring the accumulation of cGMP in T84 cell exposed to an agonist, the EC50 of linaclotide at pH 7.0 was 99±17.5 nM. In preclinical studies in mice using the transit of activated charcoal as ameasure of efficacy, linaclotide at 100 μg/kg significantly accelerated transit compared to wild-type mice treated with charcoal only or GC-Cnullmice treatedwith and without linaclotide.118 Efficacy was also seen in rats treatedwith linaclotide atdoses of 5, 10, and 20 μg/kg. Linaclotide has been synthesized using conventional solid-phase peptide technology.

Uses:

Linaclotide is an effective and selective guanylate cyclase C agonist; it was developed to treat constipation-type irritable bowel syndrome (IBS-C) and chronic constipation.

Adverse effects:

The US label has a black box warning to not use linaclotide in children less than 6 years old and to avoid in people from 6 to 18 years old, due to the risk of serious dehydration.

More than 10% of people taking linaclotide have diarrhea. Between 1% and 10% of people have decreased appetite, dehydration, low potassium, dizziness when standing up too quickly, nausea, vomiting, urgent need to defecate, fecal incontinence, and bleeding in their colon, rectum, and anus.

Company Profile

Wuhan wingroup Pharmaceutical Co.,Ltd located in Wuhan, Hubei Province, is a company dedicated to R&D,production and sales of chemical reagents, pharmaceutical intermediates, plantextracts and chemical raw materials. The company has a long-term cooperationwith Wuhan Research Institute and other universities. It is a pharmaceuticalenterprise oriented by the global pharmaceutical market demand and integratingthe research and development, industrialization and market operation ofinnovative drugs. At present, the company has submitted 10 domestic patents andone PCT patent (International Patent); And obtained the authorization of 7invention patents. The company has strong technical strength, advanced equipment,strict quality management system and high-quality after-sales service.

Over the years, our products have been widely sold to many countries and regions that we have established stable relations of cooperation with the traders and end users all around the world and have become a solid bridge among the suppliers, traders and end users.

Our Advantages

1. Quality control: We take quality as our life. We strictly control the quality of each process and establish a complete quality control system. We promise to bring 100% best quality products to consumers.

2. Trade capacity: We focus on chemical, biological medicine international trade for more than 10 years. Has the abundant product and the trade ability. Cooperative customers all over the world, good reputation.

3. transport capacity: We have professional freight agents, customs clearance agencies set up in the destination. Deliver your package safely. According to the customer's transport needs can choose: FEDEX UPS TNT DHL  air charter and sea.

4. Carefully packing: 1kg, 5kg, 15kg, 20kg, 25kg can be packed in different specifications. Packaging can be customized according to customer requirements. Aluminum foil bag and carton. Ensure the safety of transportation. And free samples are available.

5. Quality service: We have a professional customer service team and after sales team. Being proficient in each language will guarantee your after-sale service.

Certificate

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Packing&Shipping

1.Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);

2.Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).

3.Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg,NW: 1kg).

1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post andother couriers, weight from 10g to 1000kg or even bulker.

2. Shipping details & shipping documents will be provided andsent by email.

3.We keep tracking the shippment until clients well received.

4.After years export shipping experience, with professional and experienced cooperated forwarders,we ensure that goods can be  delivered in multiple ways safetly and efficiently.

FAQ

Q1:Can I get some samples?

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2:Which kind of payment terms do you accept?

A: Payment by T/T, Western Union or Bitcoin.

Q3:Which transportation do we use?

A:Samples could be DHL, UPS, TNT, EMS, Fedex, and so on. For mass orders, it will be delivered by air or sea.

Q4:How about your delivery time?

Generally, it will take 3 to 5 days after receiving your advance payment.

Q5:How do you treat quality complaint?

A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q6:How can we trust you?

A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited our company on-spot and approved our credit.

Q7:Do you test all your goods before delivery?

A:Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.