| Name | LF3 |
| Description | LF3 is a 4-thioureido-benzenesulfonamide derivative that acts as a small-molecule inhibitor of β-catenin/TCF4 interaction in the Wnt signaling pathway. At 10 μM, it significantly increases NaV1.5 expression and sodium channel activity in cardiomyocytes by blocking the β-catenin/TCF4 complex, while in vascular and fibrotic models, it suppresses cell proliferation, migration, and ECM deposition without altering β-catenin or TCF4 protein levels. Research applications include investigating Wnt-driven fibrosis, cardiac arrhythmia mechanisms, ferroptosis-combined cancer therapy, and host-virus genetic diversity in Epstein-Barr virus LF3 gene studies. |
| Animal Research | Unsorted GFPlow and GFPhigh SW480 cells (1 × 10^4) were subcutaneously injected into the back skin of NOD/SCID mice. Tumor growth was monitored over a period of 45 days. For therapy, LF3 was administered i.v. at 50 mg/kg body weight for three rounds over 5 consecutive days, with 2-day breaks[1]. |
| In vitro | LF3 inhibited Wnt/β-catenin signals in cells with exogenous reporters and in colon cancer cells with endogenously high Wnt activity. LF3 also suppressed features of cancer cells related to Wnt signaling, including high cell motility, cell-cycle progression, and the overexpression of Wnt target genes[1]. |
| In vivo | LF3 reduced tumor growth and induced differentiation in a mouse xenograft model of colon cancer.LF3 is a specific inhibitor of canonical Wnt signaling with anticancer activity[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (24.01 mM), Solution.
10% DMSO+90% Saline : < 10 mg/mL (24.01 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
DMSO : 250 mg/mL (600.15 mM), Sonication is recommended.
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| Keywords | β-catenin | βcatenin | Wnt/β-catenin | Wnt/betacatenin | Wnt/b-catenin | Wnt | LF-3 | LF3 | LF 3 | Inhibitor | inhibit | beta-catenin | betacatenin | Beta catenin | bcatenin |
| Inhibitors Related | Chlorquinaldol | Urea | Wnt pathway activator 1 | Neohesperidin | XAV-939 | Ethyl linoleate | Monensin sodium salt | Nimbolide | Isoquercetin | (±)-Nornicotine | Methyl Vanillate | Bisdemethoxycurcumin |
| Related Compound Libraries | Bioactive Compounds Library Max | Anti-Colorectal Cancer Compound Library | Osteogenesis Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Metabolism Compound Library | Bioactive Compound Library | Neuroprotective Compound Library | Inhibitor Library | Anti-Prostate Cancer Compound Library | PPI Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library |
United States
