| Name | Levomenol |
| Description | Levomenol ((-)-α-BISABOLOL) is a sesquiterpene alcohol that has been found in the essential oils of several aromatic plants, with exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. |
| In vitro | Levomenol was able to activate a programmed cell death process in the promastigote stage of the parasite.It causes phosphatidylserine externalization and membrane damage.Moreover, it decreases the mitochondrial membrane potential and total ATP levels.These results highlight the potential use of Levomenol against both L. amazonensis and L. infantum, and further studies should be undertaken to establish it as novel leishmanicidal therapeutic agents[1]. |
| In vivo | Levomenol inhibits the growth of L. amazonensis promastigotes and amastigotes (IC50s = 8.07 and 4.29 μg/ml, respectively). It also reduces the growth of L. infantum and L. donovani amastigotes (IC50s = 56.9 and 39.4 μM, respectively) with a cytotoxic concentration (CC50) value of greater than 1,000 μM in L929 cells[2]. |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.99 mM), Sonication is recommended.
DMSO : 22.5 mg/mL (101.18 mM), Sonication is recommended.
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| Keywords | α-BISABOLOL | unsaturated sesquiterpene alcohol | oral | neuroprotective effects | Levomenol | Inhibitor | inhibit | Apoptosis | antioxidant | anti-inflammatory | alpha-BISABOLOL | a-BISABOLOL |
| Inhibitors Related | Stavudine | Aceglutamide | Tamoxifen | Urea | Cysteamine hydrochloride | Gum arabic | Sodium 4-phenylbutyrate | Metronidazole | Citric Acid Triammonium | Dimethyl phthalate | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Pain-Related Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Natural Product Library | Drug Repurposing Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Flavor Natural Product library | Bioactive Compounds Library Max |
United States
