ChemicalBook CAS DataBase List 23089-26-1

23089-26-1

Name	(-)-ALPHA-BISABOLOL
CAS	23089-26-1
EINECS(EC#)	245-423-3
Molecular Formula	C15H26O
MDL Number	MFCD03412455
Molecular Weight	222.37
MOL File	23089-26-1.mol

Synonyms

A-(-)-BISABOLOL (-)-ALPHA-BISABOLOL ALPHA-(-)-BISABOLOL BISABOLOL, A-(-)- BISABOLOL OXIDE A CAMILLOL DRAGOSANTOL HYDAGEN B LEVOMENOL .alpha.-4-dimethyl-.alpha.-(4-methyl-3-pentenyl)-,[S-(R*,R*)]-3-Cyclohexene-1-methanol [S-(R*,R*)]-alpha,4-Dimethyl-alpha-(4-methyl-3-pentenyl)cyclohex-3-ene-1-methanol [S-(R*,R*)]-alpha-Bisabolol 1-Methyl-4-(1,5-dimethyl-1-hydroxyhex-4(5)-enyl)cyclohexen-1 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)- 3-Cyclohexene-1-methanol, alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-, [S-(R*,R*)]- alpha,4-dimethyl-alpha-(4-methyl-3-pentenyl)-3-cyclohexene-1-methano[s-( alpha-Bisabolol (-)-form Kamillosan theta)]-thet levomenol,β-bisabolol

Chemical Properties

alpha	D -55.7°; D20 -51.02° (Günther)
Boiling point	bp12 153°
density	d20 0.9211
vapor pressure	0.015Pa at 20℃
FEMA	4666 \| ALPHA-BISABOLOL
refractive index	n20/D 1.496
Fp	135 °C
storage temp.	-20°C
solubility	DMSO:100.0(Max Conc. mg/mL);449.7(Max Conc. mM)
form	neat
pka	15.04±0.29(Predicted)
color	Colorless to light yellow
Odor	at 100.00 %. fruity nutty coconut
Odor Type	floral
Optical Rotation	[α]/D -60±2°, neat
Water Solubility	22mg/L at 20℃
JECFA Number	2031
Cosmetics Ingredients Functions	SKIN CONDITIONING SOOTHING FRAGRANCE
InChI	1S/C15H26O/c1-12(2)6-5-11-15(4,16)14-9-7-13(3)8-10-14/h6-7,14,16H,5,8-11H2,1-4H3/t14-,15+/m1/s1
InChIKey	RGZSQWQPBWRIAQ-CABCVRRESA-N
SMILES	O[C@]([C@H]1CCC(=CC1)C)(CCC=C(C)C)C
LogP	5.5 at 25℃
CAS DataBase Reference	23089-26-1(CAS DataBase Reference)
EPA Substance Registry System	Levomenol (23089-26-1)

Safety Data

Symbol(GHS)	GHS09
Hazard statements	H412
Precautionary statements	P273-P501
RIDADR	UN 3082 9 / PGIII
WGK Germany	3
RTECS	MJ9685000
REACH Registrations	Active
HS Code	2906195000
Storage Class	10 - Combustible liquids
Hazard Classifications	Aquatic Chronic 3
Toxicity	LD50 in male, female mice, rats (ml/kg): 15.2, 15.0, 14.9, 15.6 orally (Habersang) less more

Hazard Information

Description

Bisabolol, or more formally (-)-alpha-bisabolol, also known as levomenol, is a natural monocyclic sesquiterpene alcohol. Alpha-bisabolol, an unsaturated monocyclic sesquiterpene alcohol, is known as one of the “most-used herbal constituents” worldwide. Various therapeutic and biological properties of α-bisabolol in preventing oxidative stress, inflammatory disorders, infections, neurodegenerative diseases, cancers, and metabolic disorders have been reported. It is a common additive in many PCPs, including dental care products, skin moisturisers, sunscreens, and make-up products, due to its multiple biological activities.

Uses

(-)-α-Bisabolol was used to investigate the leishmanicidal and cytotoxic activity of essential oil of Vanillosmopsis arborea.

Uses

Reference Standard in the analysis of herbal medicinal products

Definition

ChEBI: (-)-alpha-Bisabolol is a sesquiterpenoid.

benefits

The benefits of Bisabolol (or α-bisabolol) on the skin include soothing, anti-aging, maintaining skin firmness, improving skin pigmentation and moisturising the skin to reduce the appearance of fine lines.

General Description

(-)-α-Bisabolol is the major constituent of essential oil from leaves of Hymenocrater yazdianus.

Flammability and Explosibility

Notclassified

Biochem/physiol Actions

α-Bisabolol is active against primary acute leukemia cells, including BCR-ABL(+) acute lymphoblastic leukemias. It is the inhibitor of voltage-dependent Ca(2+) channels in tracheal smooth muscle preparations of rat. It also inhibits human and rat glioma cell growth and survival. It is a potential new therapeutic agent against leishmaniasis.

storage

Store at 2-8°C

Questions And Answer

Spectrum Detail

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23089-26-1

Chemical Properties

Safety Data

Hazard Information

Description

Uses

Uses

Definition

benefits

General Description

Flammability and Explosibility

Biochem/physiol Actions

storage

Questions And Answer

Synthesis

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

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