| Name | Lactic acid |
| Description | Lactic acid (2-hydroxypropanoic acid), a glycolysis end product, is a hydroxycarboxylic acid receptor 1 (HCAR1) activator (EC50=4.2-5 mM). Lactic acid can be used as a hemodynamic index in critically ill patients and has anti-tumor activity. |
| In vitro | METHODS: : Effects on cell proliferation and migration of uveal melanoma after treatment with Lactic acid (20 mM) for 24 and 48 hours.
RESULTS: Lactic acid led to a significant reduction in cell proliferation and migration. [1]
Method: Uveal melanoma was treated with Lactic acid (20 mM) for 24 hours, and the protein expression level was detected by western blot.
Result: Lactic acid promoted the increase in the protein expression levels of MCT1 and HCAR1. [1] |
| In vivo | METHODS: To detect the anti-tumor activity in vivo, Lactic acid (1.6 g/kg) was subcutaneously injected into Female C57BL/6 mice with MC38 colon cancer cells; pH 7.4 Once a day; From Day 8 to Day 30.
RESULTS: Lactic acid demonstrated CD8+ T cell-dependent tumor growth inhibition in the MC38 colon cancer model. [2] |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90 mg/mL (999.11 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 5 mg/mL (55.51 mM), Sonication is recommeded.
H2O : 100 mg/mL (1110.12 mM), Sonication is recommended.
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| Keywords | Lactic acid |
| Inhibitors Related | Sucrose | Aceglutamide | Emtricitabine | 3-Hydroxybutyric acid sodium | Levulinic acid | D(+)-Raffinose pentahydrate | D-(+)-Trehalose dihydrate | Glycerol | Thymidine | Sodium 2-hydroxybutanoate | Chitosan oligosaccharide | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | EMA Approved Drug Library | Natural Product Library | Drug Repurposing Compound Library | Miao medicine Compound Library | Tobacco Monomer Library | FDA-Approved Drug Library | Flavor Natural Product library | Gut Microbial Metabolite Library | Anti-Cancer Drug Library |
United States
