| Name | L-Lactic acid |
| Description | L-Lactic acid ((S)-2-Hydroxypropanoic acid) is a natural product produced by the anaerobic glycolysis of pyruvic acid. L-Lactic acid is a sensitive indicator of tissue hypoxia and can be used as a hemodynamic indicator in critically ill patients. |
| In vitro | METHODS: Mouse CD4+CD25-T cells were treated with low-glucose medium containing L-Lactic acid (5-20 mM), and Teff proliferation was detected by Flow cytometry.
RESULTS: L-Lactic acid had a sustained inhibitory effect on T cell proliferation, and apoptosis-independent effect. [1]
METHODS: T cells were cultured in medium containing L-Lactic acid (20 mM), and ROS levels were measured using ROS and superoxide detection assay kits.
RESULTS: A significant reduction in ROS and O2- production was observed in L-Lactic acid-treated T cells. [2] |
| In vivo | METHODS: To study its effect on swimming endurance, L-Lactic acid (25-50 mg/kg in 0.9% NaCl) was administered intraperitoneally to ICR mice.
RESULTS: L-Lactic acid enhanced the swimming endurance of mice, and the effect was dose-dependent. [3]
METHODS: To investigate the effect on endotoxemia, L-Lactic acid (80 mg/kg) was intraperitoneally injected into mice, and 20 h later, a lethal dose of LPS (25 mg/kg) was intraperitoneally injected into mice to induce infectious shock.
RESULTS: L-Lactic acid significantly inhibited LPS-induced cytokine induction in mice following endotoxemia.L-Lactic acid treatment decreased glucose uptake and lactate output during LPS stimulation. [4] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 262 mg/mL (2908.53 mM), Sonication is recommended.
5% DMSO+95% Saline : 2.63 mg/mL (29.2 mM), Solution.
Saline : 50 mg/mL (555.06 mM), Solution.
10% DMSO+90% Saline : 5 mg/mL (55.51 mM), Solution.
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| Keywords | L-Lactic acid | LLactic acid | L Lactic acid | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Bacterial | Antibiotic | 2-Hydroxypropanoic acid |
| Inhibitors Related | Sucrose | Neomycin sulfate | Cysteamine hydrochloride | Sulfamethoxazole sodium | Terbinafine hydrochloride | Daidzein | Doxycycline | Ferulic Acid | Glycerol | Thymidine | Dimethyl sulfoxide | 3-Indoleacetic acid |
| Related Compound Libraries | Pesticide Compound Library | Bioactive Compound Library | Natural Product Library | Drug Repurposing Compound Library | Microbial Natural Product Library | FDA-Approved Drug Library | Natural Product Library for HTS | Human Endogenous Metabolite Library | Anti-infective Natural Product Library | Flavor Natural Product library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library |
United States
