名称 | L-368,899 hydrochloride |
描述 | L-368,899 hydrochloride is an orally available and selective nonpeptide oxytocin receptor (OXTR) antagonist for the prevention of preterm labor.L-368,899 hydrochloride prevents oxytocin-induced anti-anomalous pain and anti-nausea, and may be useful for the study of depression. |
体外活性 | L-368,899 hydrochloride is an effective non-peptide oxytocin receptor antagonist, with IC50 values of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptors, respectively[1]. |
体内活性 | L-368,899 (5 mg/kg; oral administration) has oral bioavailabilities of 14% and 18% in female and male rats, respectively[2]. |
存储条件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | H2O : 2 mg/mL (3.38 mM), Sonication is recommended. DMSO : 100 mg/mL (169.14 mM), Sonication is recommended.
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关键字 | L-368,899 Hydrochloride | L368,899 hydrochloride | L 368,899 hydrochloride |
相关产品 | YNT-185 | Orexin 2 Receptor Agonist | IPSU | MK-3697 | Filorexant | DORA-22 | Orexin B, rat, mouse Acetate | OXA (17-33) acetate | PF3274167 | ACT-462206 | Seltorexant | TCS 1102 |
相关库 | 经典已知活性库 | 神经信号分子库 | 抑制剂库 | 口服活性化合物库 | 已知活性化合物库 | GPCR靶点分子库 |