160312-62-9

L-368,899 is a non-peptide oxytocin receptor antagonist (IC₅₀s = 8.9 and 26 nM in radioligand binding assays using isolated human and rat uterus, respectively). It is selective for oxytocin receptors over vasopressin V_1a and V₂ receptors (IC₅₀s = 370 and 570 nM, respectively). L-368,899 reduces oxytocin-induced contraction of isolated rat uterus (pA₂ = 8.9) and in situ rat uterus (ED₅₀ = 0.35 mg/kg, i.v.).

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