| Product Name | Ivermectin |
| CAS | 70288-86-7 |
| Molecular formula | C48H74O14 |
| Molecular weight | 875.09300 |
| Grade | Pharmaceutical Grade |
| Color | White powder |
| Purity | 99% |
| Shelf life | 2 years |
Ivermectin is white crystalline powder, odorless.
Ivermectin is a medication used to treat many types of parasite infestations. Ivermectin is used to treat animals diseases caused by roundworms and ectoparasites. In veterinary medicine, it is used to prevent and treat heartworm and acariasis, among other indications. It can be taken by mouth or applied to the skin for external infestations. Ivermectin is widely used for gastrointestinal nematodes, lungworms, and parasitic arthropods in cattle, sheep, horses, and pigs, intestinal nematodes in dogs, ear mites, Sarcoptes scabiei, heart filariae, and microfilariae, and gastrointestinal nematodes and ectoparasites in poultry.
The Introductction of Ivermectin:
Ivermectin is widely used in cattle, sheep, horses, pigs, gastrointestinal nematodes, lung nematodes and parasitic arthropod, canine intestinal nematodes, ear mites, scabies mites, silk worm and microfilariae, gastrointestinal nematodes and external parasites and poultry. This product belong to the broad-spectrum resistant parasites.
Ivermectin for a variety of most of the life cycle of nematodes (but not all nematodes) role; For dish tail filarial microfilariae effectively, but for adult worms; For only in intestinal fecal round worms are also effective.
Ivermectin has the selective inhibitory effect, with no spinal nerve cells and muscle cells in the animal glutamic acid ion channels of the valve is the high binding affinity, leading to the proliferation of the chloride ion permeability of cell membrane, cause nerve cells or muscle cells hyperpolarization, parasites paralysis or death.
The Application & Function of Ivermectin:
1. Ivermectin is the derivatives of abamectin. Ivermectin belongs to semisynthetic broad-spectrum resistant parasites.
2. Ivermectin has effect for most of the various life cycle nematodes.
3. Ivermectin has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus.
4. Ivermectin has effect for dung round worms that is only stay in intestinal tract.
5. Ivermectin has selective inhibition.
6. Ivermectin can not go through the blood brain barrier of humanbeings.
In veterinary medicine ivermectin powder is used against many intestinal worms (but not tapeworms), most mites, and some lice. Despite this, it is not effective for eliminating ticks, flies, flukes, or fleas. It is effective against larval heartworms, but not against adult heartworms, though it may shorten their lives. The dose of the medicine must be very accurately measured as it is very toxic in over-dosage.
It is sometimes administered in combination with other medications to treat a broad spectrum of animal parasites. Some dog breeds (especially the Rough Collie, the Smooth Collie, the Shetland Sheepdog, and the Australian Shepherd), though, have a high incidence of a certain mutation within the MDR1 gene (coding for P-glycoprotein); affected animals are particularly sensitive to the toxic effects of ivermectin.
Clinical evidence suggests kittens are susceptible to ivermectin toxicity. A 0.01% ivermectin topical preparation for treating ear mites in cats (Acarexx) is available.
Ivermectin is sometimes used as an acaricide in reptiles, both by injection and as a diluted spray. While this works well in some cases, care must be taken, as several species of reptiles are very sensitive to ivermectin. Use in turtles is particularly contraindicated.
Other Name of Ivermectin: IVERMECTINHCL;IvermectinEP2000;IVERMECTINNOTLESSTHAN93.0%OF22,23-DIHY-DROAVERMECTINB1A,ANDNOTLESSTHAN97.0%OF22,23-DIChemicalbookHY-DROAVERMECTINB1(B1A+B1B);IVERMECTINEP(CRMSTANDARD);IVERMECTINUSP(CRMSTANDARD);IvermectineEp2000;IVOMEC;IVERMECTIN
| Tests | Specification | Results |
| Appearance | White or yellowish-white crystalline powder, slightly hygroscopic. | Yellowish-white crystalline powder, slight hygroscopic. |
| Solubility | Practically insoluble in water, soluble in alcohol. | Qualified |
| Identification | IR | Corresponds to that of CRS standard | Qualified |
| HPLC | The retention time for H2Bla and H2Blb in the chromatogram obtained with the test solution corresponds to those of standard preparation | Qualified |
| Appearance of solution | Clear and not more intensely colored than BY? | Clear |
| Specific optical rotation (anhydrous and solvent-free substance), ° | -20--17 | -17.9 |
| Related substances (%) | Individual impurity(RRT 1.3-1.5)≤2.5 | I-l:<0.05 K:2.1 |
| Any other impurity ≤ 1 | C:0.06 A:0.57
J:0.14 H:0.39 D:<0.05 F:<0.05
E:0.36 1-2:0.19 |
| Total ≤5 | 3.8 |
| Disregard limit: 0.05 |
| Ethanol and Formamide (%) | Ethanol ≤5.0 | 3.9 |
| Formamide≤3.0 | 2.5 |
| Catalyst (ug/g) | ≤1 | <1 |
| Water (%) | ≤1.0 | 0.26 |
| Sulphated ash (%) | ≤0.1 | 0.07 |
| Heavy Metal (%) | ≤0.002 | <0.002 |
| Assay (%) (HPLC, on dry basis) | H2Bla/(H2Bla +H2Blb)≥90.0 | 97.7 |
| 95.0≤H2Bla +H2Blb≤ 102.0 | 96.7 |
| Conclusion | Complies with the requirements of EP10.0 |
Hebei Jingbo New Material Technology Co., Ltd. was founded in 2007 , located in Shijiazhuang city which is the capital of Hebei Province and hub sector among Beijing Tianjin and Hebei and has advantage of convenient transportation . Our company is a modern high-tech chemical enterprise with Research & Development, production and sales.Our company has strong technical strength, advanced equipment, strict quality management system and high-quality after-sales service, adhers to the "customer first and forge ahead" business philosophy and insists on integrity as the company's survival.
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