| Name | Ivermectin |
| Description | Ivermectin (MK-933) is an activator of glutamate-gated chloride channels (GluCls) with antiparasitic activity. |
| In vitro | Ivermectin exhibits antiviral activity against HIV-1 and Dengue fever virus. It binds to a novel site on GABAA receptors in hippocampal embryonic neurons of mice, conformationally enhancing the affinity of the GABA binding site. In nematodes, the compound interacts with glutamate-gated chloride channels (GluCls), disrupting the regulation mediated by GluCl activity. |
| In vivo | Intraperitoneal injection of Ivermectin (1.25-10 mg/kg) can reduce the consumption of alcohol and saccharin. For mice exposed to lethal doses of LPS, Ivermectin inhibits LPS-induced NF-kB translocation and enhances survival rates. |
| Storage | keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 27 mg/mL (30.85 mM), Sonication is recommended.
DMSO : 45 mg/mL (51.42 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | SARS-CoV | SARSCoV | SARS coronavirus | Parasite | P2XReceptor | P2X4 | P2X Receptor | MK933 | MK 933 | Mitophagy | Mitochondrial Autophagy | Ivermectin | Inhibitor | inhibit | Human immunodeficiency virus | HSV | HIVProtease | HIV Protease | HIV | Herpes simplex virus | GluCl channels | Autophagy | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | Emtricitabine | Cysteamine hydrochloride | Adipic dihydrazide | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Metronidazole | 2-Amino-2-methyl-1-propanol | Fenpyroximate | BES |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Natural Product Library for HTS | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
