名称 | ISX-9 |
描述 | ISX-9 (Isoxazole 9) is essential for activating neuron-specific genes and serves as a neurogenesis inducer. |
细胞实验 | Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells.(Only for Reference) |
体外活性 | In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. [1] |
体内活性 | In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. [2] |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | Ethanol : 11 mg/mL (47 mM) DMSO : 40 mg/mL (170.74 mM)
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关键字 | Mef2 | ISX9 | Isoxazole-9 | Ca2+ | Isoxazole9 | Ca channels | Calcium Channel | inhibit | neuroD | NMDA | Inhibitor | ISX-9 | ISX 9 | Ca2+ channels |
相关产品 | Nisoldipine | Nimodipine | 2,5-Di-tert-butylhydroquinone | Diltiazem hydrochloride | Levetiracetam | L-Ascorbic acid | Lanthanum(III) chloride heptahydrate | Ethyl cinnamate | 1-Octanol | 1,2,4-Trihydroxybenzene | Nefopam hydrochloride | Otilonium bromide |
相关库 | 神经再生化合物库 | 经典已知活性库 | 疼痛相关化合物库 | 神经信号分子库 | 膜蛋白靶向化合物库 | 抗癌细胞代谢库 | 神经保护化合物库 | 抗前列腺癌化合物库 | 已知活性化合物库 | 离子通道库 |