GENERAL STEPS: Ethyl 5-(thiophen-2-yl)isoxazole-3-carboxylate (220 mg, 1 mmol) was dissolved in anhydrous ethanol (5 mL), followed by the addition of cyclopropylamine (285 mg, 5 mmol). The reaction mixture was sealed and heated at 80 °C for 24 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of water (1 mL). The resulting white crystalline solid, N-cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide (150 mg, 64% yield) was collected by vacuum filtration. The product NMR hydrogen spectrum (400 MHz, d6-DMSO) data were as follows: δH 8.85 (1H, d), 7.83 (1H, d), 7.76 (1H, d), 7.24 (1H, d), 7.18 (1H, s), 2.83 (1H, m), 0.58-0.71 (4H, m).
