| Name | Isoliensinine |
| Description | Isoliensinine (Isoliensinin) is a natural product, a bisbenzylisoquinoline alkaloid. Isoliensinine has antitumor, antioxidant, anti-inflammatory, and antiarrhythmic activities. |
| In vitro | METHODS: Human breast cancer cells MDA-MB-231 were treated with Isoliensinine (1-40 µM) for 24-72 h. Cell viability was measured by CCK-8 Assay.
RESULTS: Isoliensinine exhibited anticancer properties in MDA-MB-231 cells, with estimated IC50 values of 108.1 µM, 22.78 µM, and 18.34 µM at 24 h, 48 h, and 72 h, respectively. [1]
METHODS: Cervical cancer cells C33A, Caski, HeLa and SiHa were treated with Isoliensinine (5-40 µM) for 24 h. The expression levels of target proteins were detected by Western Blot.
RESULTS: Isoliensinine significantly reduced CDK2 and cyclin E at the protein level in a dose-dependent manner in the four cervical cancer cells. [2] |
| In vivo | METHODS: To investigate the effects on pulmonary fibrosis in mice, Isoliensinine (10-40 mg/kg) was orally administered three times daily for 14 days to Kungming mice with bleomycin (BLM)-induced pulmonary fibrosis.
RESULTS: Isoliensinine exerted a significant inhibitory effect on BLM-induced pulmonary fibrosis, which may be due to its antioxidant and/or anti-inflammatory activity as well as inhibition of BLM-induced overexpression of TNF-α and TGF-β1. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble
DMSO : 55 mg/mL (90.05 mM)
|
| Keywords | Apoptosis | Isoliensinine | Inhibitor | inhibit |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Sorafenib | Tributyrin | L-Cystine | Salicylic acid | Oleic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Viral Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-virus Traditional Chinese Medicine Monomer Library | Ancient Chinese Classical Formulas Compound Library |
United States
