| Name | Iobenguane sulfate |
| Description | Iobenguane sulfate (MIBG sulfate) is a high-affinity substrate for cholera toxin that disrupts cellular mono(ADP-ribosylation). Radioiodinated Iobenguane sulfate is used clinically as a tumor-targeted radiopharmaceutical for diagnosing and treating adrenergic tumors. |
| In vitro | Iobenguane sulfate is an effective effector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range. Iobenguane sulfate (2-20 μg/ml; 72 hours) suppresses cell growth in a panel of human and mouse leukemia, melanoma, fibrosarcoma, and neuroblastoma cell lines. |
| In vivo | Iobenguane sulfate (20 mg/kg; i.p.; daily on days 3-6) displays antitumor activity. Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg. The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of survival but no cures were observed. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (12.34 mM), Sonication is recommended.
DMSO : 100 mg/mL (308.52 mM), Sonication is recommended.
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| Keywords | tumors | survival | proliferation | mono(ADP-ribosylation) | MIBG Sulfate | MIBG | Iobenguane Sulfate | Iobenguane sulfate | Iobenguane | Inhibitor | inhibit | cytotoxic | antitumor | analogue | adrenergic |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Approved Drug Library | ReFRAME Related Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
