| Name | Ribostamycin sulfate |
| Description | Ribostamycin sulfate (Vistamycin sulfate) , an aminoglycoside antibiotic, contains a neutral sugar moiety and is produced by Streptomyces ribosome. |
| In vitro | Ribostamycin, as an intermediate in the biosynthesis of neomycin, can inhibit the chaperone activity of protein disulfide isomerase (PDI) but does not inhibit its isomerase activity. At a concentration of 256 µg/mL, it exhibits almost no toxicity to HUVEC cells. |
| In vivo | Compared to other antibiotics, Ribostamycin (400 mg/kg/day) causes the lowest ototoxicity, as its drug concentration in the inner ear fluid of guinea pigs is relatively low. Ribostamycin exhibits the least ototoxicity to the cochlea and vestibular organs of guinea pigs. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10%DMSO + 90% Saline : 100 mg/mL (180.98 mM), Sonication is recommended. DMSO : Insoluble PBS : 100 mg/mL (180.98 mM), Sonication is recommended. H2O : 100 mg/mL (180.98 mM), Sonication is recommended.
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| Keywords | Vistamycin Sulfate | Vistamycin | Ribostamycin sulfate | Ribostamycin Sulfate | Ribostamycin | Inhibitor | inhibit | Bacterial | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Doxycycline (hyclate) | Kanamycin sulfate | Urethane | Sulfamethoxazole sodium | Doxycycline | EDTA copper(II) disodium salt | Isoeugenol | Dimethyl sulfoxide |
| Related Compound Libraries | Bioactive Compound Library | Saccharide and Glycoside Natural Product Library | Natural Product Library | Drug Repurposing Compound Library | Microbial Natural Product Library | Anti-Bacterial Compound Library | NO PAINS Compound Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |