Description:
Nintedanib, also known by its brand name Ofev, is a pharmaceutical compound extensively used for the management of various fibrotic diseases, particularly those affecting the lungs. Its primary applications include treating idiopathic pulmonary fibrosis (IPF), systemic sclerosis-associated interstitial lung disease (SSc-ILD), and other chronic fibrosing interstitial lung diseases that exhibit progressive characteristics.
Research and Development:
The development of Nintedanib represents a significant milestone in the field of pulmonary medicine due to its unique mechanism of action. It targets multiple tyrosine kinases involved in pathways that lead to fibrosis. Specifically, Nintedanib inhibits receptors like VEGFR (Vascular Endothelial Growth Factor Receptor), PDGFR (Platelet-Derived Growth Factor Receptor), and FGFR (Fibroblast Growth Factor Receptor). These receptors are crucial in processes such as angiogenesis, cell proliferation, migration, and survival - all of which contribute to the pathological scarring observed in fibrotic diseases.
Clinical Use:
Nintedanib's approval for medical use was based on robust clinical trials demonstrating its efficacy in slowing down the progression of lung fibrosis. For patients with IPF or SSc-ILD, this can mean a significant improvement in quality of life and potentially prolonged survival by delaying disease worsening measured through forced vital capacity decline or acute exacerbations.
Ongoing Research:
Beyond its current indications, ongoing research explores Nintedanib's potential benefits across a broader spectrum of fibrotic conditions. These include liver cirrhosis due to non-alcoholic steatohepatitis (NASH) among others. The anti-fibrotic properties exhibited by Nintedanib suggest it may have utility across various organ systems beyond the lungs where excessive tissue scarring is a key component of disease pathology.
Product Forms: Oral Capsules/Tablets
Payment method: T/T in advance, Paypal, Western Union, L/C, etc.
Shipping ways: Courier, Air, Sea, Road
Storage Condition: Dry, dark, and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
China
